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Placental Lactogen Recombinant Rabbit mAb (bsm-60796R)  
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25ul/800.00元
50ul/1400.00元
100ul/2500.00元
大包装/询价

产品编号 bsm-60796R
英文名称 Placental Lactogen Recombinant Rabbit mAb
中文名称 人胎盘泌乳素重组兔单克隆抗体
别    名 choriomammotropin; Chorionic somatomammotropin A; chorionic somatomammotropin; Chorionic somatomammotropin hormone 1(placental lactogen); chorionic somatomammotropin hormone 1; Chorionic somatomammotropin hormone 2; CS 1; CS-2; CS-B; CSA; CSB; CSH1; CSMT;  
抗体来源 Rabbit
克隆类型 Recombinant
克 隆 号 C8D6
交叉反应 Human
产品应用 WB=1:500-1000,IHC-P=1:200-1000,IHC-F=1:200-1000,IF=1:200-1000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 22 kDa
检测分子量
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Placental lactogen 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 PBS, Glycerol, BSA.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Placental lactogens, also referred to as chorionic somatomammotropin hormones, are protein hormones. They are produced in the mammalian placenta and are similar in structure and function to growth hormones. Together, placental lactogens and growth factors play an essential role to assure successful lactation after pregnancy. Placental lactogens also modify the metabolic state of the mother during pregnancy to supply energy to the fetus. Placental lactogen I is a member of the somatotropin/prolactin family of hormones. The proteins in this family are crucial in mammalian growth control. Placental lactogen I is expressed primarily during mid-pregnancy, and it has been reported that DNA methylation regulates its tissue expression in rats. Placental lactogen II is expressed later in pregnancy and, in mice, its secretion is regulated by the inhibitory control of GH, the concentration of which increases rapidly at the beginning of the last half of pregnancy.

Function:
Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. Does not interact with GHR but only activates PRLR through zinc-induced dimerization.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed in placenta, maternal decidua and fetal membranes. Within placenta, expressed in trophoblasts, stromal cells, villous endothelium, syncytiotrophoblast apical membrane and villous stroma. Within fetal membranes, expressed in amnion, chorioamniotic mesenchyma and chorion (at protein level). Expressed in cardiac, smooth, and skeletal muscle, neurons, thymus, kidney and hematopoietic cells.

Similarity:
Belongs to the somatotropin/prolactin family.

SWISS:
P0DML3

Gene ID:
1443

Database links:

Entrez Gene: 1442 Human

Entrez Gene: 1443 Human

Omim: 150200 Human

SwissProt: P0DML3 Human

Unigene: 654390 Human



产品图片
Paraformaldehyde-fixed, paraffin embedded (human placenta); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Incubation with (Placental Lactogen) Monoclonal Antibody, Unconjugated (bsm-60796R) at 1:500 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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