| 产品编号 | bs-43607P |
| 英文名称 | Recombinant mouse IL2RA protein, C-His (HEK293) |
| 中文名称 | 重组小鼠白介素2受体a链蛋白 |
| 别 名 | Interleukin 2 receptor alpha chain; CD 25; CD25 antigen; IDDM10; IL 2 RA; IL 2 receptor alpha subunit; IL2 RA; IL-2RA; IL2R; IL2RAC; Interleukin 2 Receptor Alpha; Interleukin 2 receptor alpha chain; Interleukin 2 receptor; Ly43; p55; T Cell Growth Factor |
| 理论分子量 | 25.8 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | >0.5mg/ml |
| 物 种 | Mouse |
| 纯 度 | >90% as determined by SDS-PAGE |
| 纯化方法 | AC |
| 内毒素 | Not analyzed |
| 表达系统 | HEK293 cell |
| 标签 | C-His |
| 缓 冲 液 | PBS (pH7.4). |
| 保存条件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] SWISS: P01590 Gene ID: 16184 CD25抗原是分子量为55KD的单链糖蛋白，故又称白介素2受体。主要用于与淋巴样肿瘤、自身免疫性疾病及同种异体移植排斥反应等疾病的研究。CD25是白介素受体的α亚单位，主要表达于活化的T细胞，在活化的B细胞、NK细胞和巨噬细胞也有一定量的表达。该抗体主要用于标记活化的淋巴细胞。 |
| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
|
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
