产品编号 |
bs-43157P |
英文名称 |
Recombinant SARS-Cov-2 Spike RBD protein (BQ.1.1/Omicron), His (HEK293)
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中文名称 |
重组SARS冠状病毒2 Spike突变蛋白RBD(BQ.1.1/Omicron) |
别 名 |
SARS-CoV-2 spike protein; 2019-nCOV Spike protein; Spike glycoprotein; Spike protein S1; Surface glycoprotein; Spike protein RBD; SPIKE_SARS2 |
克 隆 号 |
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理论分子量 |
26.7 kDa |
检测分子量 |
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性 状 |
Lyophilized or Liquid |
物 种 |
SARS-Cov-2 |
纯 度 |
>90% as determined by SDS-PAGE |
内毒素 |
Not analyzed |
表达系统 |
HEK293 cell |
标签 |
C-His |
保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
产品介绍 |
The ongoing coronavirus disease 2019 (COVID-19) pandemic has prioritized the development of small-animal models for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The resulting mouse-adapted strain at passage 6 (called MASCp6) showed increased infectivity in mouse lung and led to interstitial pneumonia and inflammatory responses in both young and aged mice after intranasal inoculation. Deep sequencing revealed a panel of adaptive mutations potentially associated with the increased virulence. In particular, the N501Y mutation is located at the receptor binding domain (RBD) of the spike protein.
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产品图片 |
Measured by its binding ability in a functional ELISA. Immobilized human ACE2, His-Avi Tag (Cat: bs-46001P) at 2μg/mL (100 μL/Well) can bind SARS-CoV-2 Spike RBD (BQ.1.1/Omicron), His Tag (Cat: bs-43157P), the EC50 is 34ng/mL.
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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