| 产品编号 |
bs-42114P |
| 英文名称 |
Recombinant human RIPK1 protein, N-His
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| 中文名称 |
重组丝氨酸苏氨酸激酶1受体相互作用蛋白 |
| 别 名 |
Cell death protein RIP; Receptor (TNFRSF) interacting serine threonine kinase 1; Receptor interacting protein; Receptor interacting serine threonine protein kinase 1; Receptor TNFRSF interacting serine threonine kinase 1; Receptor-interacting protein 1; Receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; Rip-1; RIPK 1; RIPK-1; RIPK1_HUMAN; Serine threonine protein kinase RIP; Serine/threonine-protein kinase RIP. |
| 克 隆 号 |
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| 理论分子量 |
28.7 kDa |
| 性 状 |
Lyophilized or Liquid |
| 浓 度 |
>1mg/ml |
| 物 种 |
Human |
| 纯 度 |
>90% as determined by SDS-PAGE |
| 内毒素 |
Not analyzed |
| 表达系统 |
E.coli |
| 活性 |
Not tested |
| 标签 |
C-His |
| 缓 冲 液 |
20mM Tris (pH8.0) with 8M Urea. |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
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| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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