| 产品编号 | bs-41293R |
| 英文名称 | Rabbit Anti-NLRP3 antibody |
| 中文名称 | 细胞凋亡诱导蛋白NALP3抗体 |
| 别 名 | LRR and PYD domains-containing protein 3; AGTAVPRL; AII/AVP antibody Angiotensin/vasopressin receptor AII/AVP like; Angiotensin/vasopressin receptor AII/AVP-like; C1orf7; Caterpiller protein 1.1; CIAS 1; CIAS1; CLR1.1; Cold autoinflammatory syndrome 1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; Familial cold autoinflammatory syndrome; FCAS; FCU; Muckle-Wells syndrome; MWS; NACHT; NACHT LRR and PYD containing protein 3; NALP 3; NALP3; NALP3_HUMAN; NLRP3; PYPAF 1; PYPAF1 antibody PYRIN containing APAF1 like protein 1; PYRIN-containing APAF1-like protein 1. |
 |
Specific References (6) | bs-41293R has been referenced in 6 publications.
[IF=17.694] Mahalingam, S. S.. et al. Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV. NAT COMMUN. 2023 Jan;14(1):1-15 FCM ; Human.
[IF=8.025] Lihui Ni. et al. The combination of insulin and linezolid ameliorates Staphylococcus aureus pneumonia in individuals with diabetes via the TLR2/MAPKs/NLRP3 pathway. INT J BIOL MACROMOL. 2023 Jul;242:124750 WB ; Mouse.
[IF=6.073] Huang Li. et al. Gut microbiota decreased inflammation induced by chronic unpredictable mild stress through affecting NLRP3 inflammasome. FRONT CELL INFECT MI. 2023 May;13:558 WB ; Rat.
[IF=5.955] Yan Zhang. et al. miRNA155-5P participated in DDX3X targeted regulation of pyroptosis to attenuate renal ischemia/reperfusion injury.. AGING-US. 2023 May;15: WB ; Human.
[IF=3.197] Xiang Wu. et al. NLRP3 inflammasome inhibitor MCC950 reduces cerebral ischemia/reperfusion induced neuronal ferroptosis. NEUROSCI LETT. 2023 Jan;795:137032 WB, IF ; Mouse.
[IF=2.21] Qiangbin Zhu. et al. Expression of histone H1 in rats with traumatic brain injury and the effect of the NLRP3 inflammasome pathway. WORLD NEUROSURG. 2022 Dec;: WB ; Rat.
|
| 研究领域 | 心血管 细胞生物 免疫学 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human |
| 产品应用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 114kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | Recombinant human NLRP3: 937-1036/1036 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
Subcellular Location : Cytoplasm. Tissue Specificity: Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells and osteoblasts. Undetectable or expressed at a lower magnitude in B- and T-lymphoblasts, respectively. High level of expression detected in chondrocytes. Detected in non-keratinizing epithelia of oropharynx, esophagus and ectocervix and in the urothelial layer of the bladder. Similarity: Belongs to the NLRP family. Contains 1 DAPIN domain. Contains 9 LRR (leucine-rich) repeats. Contains 1 NACHT domain. SWISS: Q96P20 Gene ID: 114548 Database links: Entrez Gene: 114548 Human Entrez Gene: 216799 Mouse Omim: 606416 Human SwissProt: Q96P20 Human SwissProt: Q8R4B8 Mouse Unigene: 159483 Human Unigene: 54174 Mouse |
| 产品图片 |
Sample:
Lane 1: Recombinant human NALP3 protein, His
Primary: Anti-NLRP3 (bs-41293R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 114 kDa
Observed band size: 11 kDa
|
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
