| 产品编号 |
bsk12026 |
| 英文名称 |
Mouse IL-21 ELISA Kit
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| 中文名称 |
小鼠白细胞介素21酶联免疫试剂盒 |
| 别 名 |
IL21, CVID11, IL-21, Za11, interleukin 21 |
| 种 属 |
Mouse |
| 线性范围 |
31.25-2000 pg/mL |
| 应用范围 |
S/P/CC |
| 检测限 |
16 pg/mL |
| 适用样品基质 |
cell culture supernates, serum, and plasma. |
| 保存条件 |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Shipped with wet ice.). |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Interleukin-21 is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells.This cytokine induces cell division/proliferation in its target cells.It has been shown that IL-21R knock-out mice express higher levels of IgE and lower levels of IgG1 than normal mice after antigen exposure. IgE levels decreased after mice were injected with IL-21. This has implications for the role of IL-21 in controlling allergic responses because of the role of IgE in hypersensitivity type 1 responses.IL-21 has been tried as therapy for alleviating allergic responses. It was shown to be successful in decreasing pro-inflammatory cytokines produced by T cells in addition to decreasing IgE levels in a mouse model for rhinitis (nasal passage inflammation).A study using mice with peanut allergies showed that systemic treatment of IL-21 was an effective means of mitigating the allergic response.This has strong implications for the pharmacological development of IL-21 for controlling both localized and systemic allergies.
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