| 产品介绍 |
Interleukin-5(IL-5)is a secreted glycoprotein that belongs to the α-helical group of cytokines. Unlike other family members, it is present as a covalently linked antiparallel dimer. The cDNA for human IL-5 encodes a signal peptide and a 115 amino acid (aa) mature protein. Mature human IL-5 shares 70%, 70%, 62%, 71%, 70% and 66%, aa sequence identity with mouse, rat, canine, equine, feline and porcine IL-5, respectively and shows cross-reactivity with mouse IL-5. IL-5 is primarily produced by CD4+ Th2 cells, but also by activated eosinophils, mast cells, EBV-transformed B cells, Reed-Sternberg cells in Hodgkin’s disease, and IL-2-stimulated invariant natural killer T cells (iNKT). IL-5 increases production and mobilization of eosinophils and CD34+ progenitors from the bone marrow and causes maturation of eosinophil precursors outside the bone marrow. The receptor for human IL-5, mainly expressed by eosinophils, but also found on basophils and mast cells, consists of a unique ligand-binding subunit (IL-5 Rα) and a shared Signaltransducing subunit, βc. IL-5 Rα first binds IL-5 at low affinity, then associates with preformed βc dimers, forming a high-affinity receptor. IL-5 also binds proteoglycans, potentially enhancing its activity. Soluble forms of IL-5 Rα antagonize IL-5 and can be found in vivo. In humans, IL-5 primarily affects cells of the eosinophilic lineage, and promotes their differentiation, maturation, activation, migration and survival, while in mice IL-5 also enhances Ig class switching and release from B1 cells. IL-5 also promotes differentiation of basophils and primes them for histamine and leukotriene release .
白介素 (IL) 5是一种主要在特应性疾病中起致病作用的细胞因子 ,又名Ｂ细胞分化因子 - μ、Ｂ细胞生长因子 2、Ｔ细胞替代因子、嗜酸粒细胞集落刺激因子 1、嗜酸粒细胞分化因子等。它调控着嗜酸粒细胞的产生、活化和分布 ,对Ｂ细胞、Ｔ细胞、嗜酸粒细胞、嗜碱粒细胞具有多种生物学功能。Azuma等于1986年克隆成功，是一种具有 白介素5多种生物学功能的淋巴因子。根据IL-5的作用，它被命名为T细胞替代因子（TRF）、B细胞生长因子Ⅱ（BCGFⅡ），嗜酸性粒细胞分化因子（EDF）和IgA增强因子。
|
