| 产品编号 | bs-23671R |
| 英文名称 | CCR3 Rabbit pAb |
| 中文名称 | 细胞表面趋化因子受体3抗体 |
| 别 名 | CCR-3; CC chemokine receptor 3; Chemokine(C-C motif) receptor 3; MIP-1 alpha receptor like-2; B chemokine receptor; b-chemokine receptor; C C chemokine receptor type 3; C C CKR 3; C-C chemokine receptor type 3; CC chemokine receptor type 3; CC CKR 3; CC R3; CCCKR3; CCR 3; CCR3; CCR3_MOUSE; CD 193; CD193 antigen; chemokine(C-C motif) receptor 3; Chemokine(CC) receptor 1 like 2; Chemokine CC motif receptor 3; Chemokine receptor 3; CK R3; CKR 3; CMKB R3; CMKBR 3; CMKBR1L2; CMKBR3; Eosinophil CC chemokine receptor 3; Eosinophil eotaxin receptor; Eotaxin receptor; Macrophage inflammatory protein 1 alpha receptor like 2; MGC102841; MIP1 alpha RL2; Probable C-C chemokine receptor type 3; C-C CKR-3; CC-CKR-3; CCR-3; CKR3; Macrophage inflammatory protein 1-alpha receptor-like 2; MIP-1 alpha RL2; CD193. |
| 研究领域 | 肿瘤 免疫学 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse (predicted: Rat) |
| 产品应用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 41 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse CCR3: 131-230/355 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3(CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants encoding the same protein have been described. Function: Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Subunit: Binds to HIV-1 Tat. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: In eosinophils as well as trace amounts in neutrophils and monocytes. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P51678 Gene ID: 12771 Database links: Entrez Gene: 1232 Human Entrez Gene: 12771 Mouse Omim: 601268 Human SwissProt: P51677 Human SwissProt: P51678 Mouse Unigene: 506190 Human Unigene: 57050 Mouse Unigene: 9890 Rat |
| 产品图片 |
Sample:
Lane 1: Mouse Lymph node tissue lysates
Lane 2: Mouse Lung tissue lysates
Primary: Anti-CCR3 (bs-23671R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 41 kDa
Observed band size: 59 kDa
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
