| 产品编号 |
bs-41083P |
| 英文名称 |
Recombinant human PEDF protein, His
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| 中文名称 |
重组人色素上皮源性因子蛋白 |
| 别 名 |
pigment epithelium-derived factor; Serpin-F1; Stromal cell-derived factor 3; SDF-3; Caspin; Alpha 2 antiplasmin; EPC 1; EPC1; PIG 35; PIG35; Pigment epithelium derived factor; Proliferation inducing protein 35; SERPIN F1; Serpin peptidase inhibitor clade |
| 克 隆 号 |
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| 理论分子量 |
45.2 kDa |
| 检测分子量 |
55 |
| 性 状 |
Lyophilized or Liquid |
| 物 种 |
Human |
| 序 列 |
20-418/418 |
| 纯 度 |
>95% as determined by SDS-PAGE |
| 纯化方法 |
AC |
| 内毒素 |
Not analyzed |
| 表达系统 |
E.coli |
| 活性 |
Not tested |
| 标签 |
His |
| 缓 冲 液 |
20mM Tris-HCl (pH8.0) with 8M Urea. |
| 保存条件 |
Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事项 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 |
Pigment epithelium derived factor, originally identified in conditioned medium of cultured human fetal retinal pigment epithelial (RPE) cells, is a neurotrophic protein that induces extensive neuronal differentiation in human Y79 retinoblastoma cells, a neoplastic counterpart of normal retinoblasts. It has been suggested that PEDF is synthesized by RPE cells and secreted into the retina interphotoreceptor matrix where it may influence development/differentiation of the neural retina. PEDF is a potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. The PEDF gene is a member of the serpin gene family. Serpins are a group of serine protease inhibitors, some of which have also been reported to exhibit neurotrophic activity.
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| 产品图片 |
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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