产品编号 | bsm-51207M |
英文名称 | LOX |
中文名称 | 蛋白赖氨酸-6-氧化酶单克隆抗体 |
别 名 | LYOX_HUMAN; Protein-lysine 6-oxidase; EC:1.4.3.13; Lysyl oxidase; Protein-lysine 6-oxidase, long form; Protein-lysine 6-oxidase, short form; AAT10; |
研究领域 | 肿瘤 心血管 细胞生物 免疫学 信号转导 |
抗体来源 | Mouse |
克隆类型 | Monoclonal |
克 隆 号 | 4C3 |
交叉反应 | (predicted: Human,Mouse,Rat,Pig) |
产品应用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理论分子量 | 29kDa |
细胞定位 | 细胞外基质 分泌型蛋白 |
性 状 | Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human LOX |
亚 型 | IgG2b |
纯化方法 | affinity purified by Protein G |
缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
产品介绍 |
This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. [provided by RefSeq, Jul 2016] Function: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. In addition to cross-linking of extracellular matrix proteins, may have a direct role in tumor suppression. Subcellular Location: Secreted; extracellular space Tissue Specificity: Heart, placenta, skeletal muscle, kidney, lung and pancreas. Post-translational modifications: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Proteolytically activated by BMP1 (By similarity). Similarity: Belongs to the lysyl oxidase family. SWISS: P28300 Gene ID: 4015 Database links: Entrez Gene: 396474 Chicken Entrez Gene: 4015 Human Entrez Gene: 16948 Mouse Omim: 153455 Human SwissProt: Q05063 Chicken SwissProt: P28300 Human SwissProt: P28301 Mouse Unigene: 102267 Human Unigene: 172 Mouse Unigene: 11372 Rat |
1、抗体溶解方法 | |
2、抗体修复方式 | |
3、常用试剂的配制 | |
4、免疫组化操作步骤 | |
5、免疫组化问题解答 | |
6、Western Blotting 操作步骤 | |
7、Western Blotting 问题解答 | |
8、关于肽链的设计 | |
9、多肽的溶解与保存 | |
10、酶标抗体效价测定程序 | |