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PPME1 Rabbit pAb (bs-19988R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-19988R
英文名称 PPME1 Rabbit pAb
中文名称 蛋白磷酸酶PPME1抗体
别    名 PME 1; PME-1; PME1; PPME1; PPME1_HUMAN; Protein phosphatase methylesterase 1.  
研究领域 肿瘤  细胞生物  信号转导  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human,Mouse (predicted: Rat,Rabbit,Sheep,Cow,Dog,Horse)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 42 kDa
检测分子量
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PPME1: 151-250/386 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Function:
Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro).

Subunit:
Binds PPP2CA and PPP2CB.

Post-translational modifications:
Phosphorylated by SIK1 following increases in intracellular sodium, leading to dissociation from the protein phosphatase 2A (PP2A) complex and subsequent dephosphorylation of sodium/potassium-transporting ATPase ATP1A1.

Similarity:
Belongs to the AB hydrolase superfamily.

SWISS:
Q9Y570

Gene ID:
51400

Database links:

Entrez Gene: 535390 Cow

Entrez Gene: 51400 Human

Entrez Gene: 72590 Mouse

Entrez Gene: 361613 Rat

Omim: 611117 Human

SwissProt: Q58DN4 Cow

SwissProt: Q9Y570 Human

SwissProt: Q8BVQ5 Mouse

SwissProt: Q4FZT2 Rat

Unigene: 503251 Human

Unigene: 177502 Mouse



产品图片
Sample:Cerebrum (Mouse)Lysate at 40 ug Primary: Anti-PPME1(bs-19988R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 42kD Observed band size: 42kD
Sample: DU145(Human) Cell Lysate at 40 ug Primary: Anti-PPME1 (bs-19988R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 42 kD
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