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Rabbit Anti-SLC16A11  antibody (bs-19798R)  
~~~促销代码KT202411~~~
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订购QQ:  400-901-9800
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-19798R
英文名称 Rabbit Anti-SLC16A11  antibody
中文名称 溶质载体家族蛋白16成员A11抗体
别    名 FLJ90193; MCT 11; Monocarboxylate transporter 11; MOT11_HUMAN; SLC16A11; Solute carrier family 16 member 11 (monocarboxylic acid transporter 11); Solute carrier family 16 member 11.  
研究领域 细胞生物  信号转导  糖尿病  内分泌病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human)
产品应用 IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 48kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SLC16A11: 331-430/471 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 SLC16A11 (Solute Carrier Family 16 Member 11) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A7. Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.

Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates.

Subcellular Location:
Cell membrane.

Tissue Specificity:
Expressed in liver, salivary gland and thyroid.

DISEASE:
Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345).
Disease description:A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Similarity:
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

SWISS:
Q8NCK7

Gene ID:
162515

Database links:

Entrez Gene: 162515 Human

Entrez Gene: 216867 Mouse

Entrez Gene: 287450 Rat

Omim: 615765 Human

SwissProt: Q8NCK7 Human

SwissProt: Q5NC32 Mouse

Unigene: 336564 Human

Unigene: 289238 Mouse

Unigene: 89414 Rat



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