| 产品编号 | bs-18450R |
| 英文名称 | LXR beta Rabbit pAb |
| 中文名称 | 肝脏X受体β抗体 |
| 别 名 | Liver X nuclear receptor beta; Liver X receptor beta; Liver X receptor beta; LX receptor beta; LXR b; LXR beta; LXRB; NER 1; NER; NER I; NER1; NERI; NR1H 2; NR1H; NR1H2; NR1H2 protein; NR1H2_HUMAN; Nuclear orphan receptor LXR beta; Nuclear orphan receptor LXR beta; Nuclear receptor NER; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; OR-1; Oxysterols receptor LXR beta; Oxysterols receptor LXR-beta; RIP 15; RIP15; steroid hormone nuclear receptor NER; Ubiquitously expressed nuclear receptor; Ubiquitously-expressed nuclear receptor; UENR; UNR. |
| 研究领域 | 肿瘤 细胞生物 细胞膜受体 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Mouse (predicted: Human,Rat,Pig,Sheep,Cow,Dog) |
| 产品应用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 51 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞核 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human LXR beta: 361-460/460 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010] Function: Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Subunit: Forms a heterodimer with RXR. Subcellular Location: Nucleus. Tissue Specificity: Ubiquitous. Similarity: Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: P55055 Gene ID: 7376 Database links: Entrez Gene: 7376 Human Omim: 600380 Human SwissProt: P55055 Human Unigene: 432976 Human Unigene: 786 Rat |
| 产品图片 |
Sample: small intestine (Mouse) Lysate at 40 ug
Primary: Anti-LXR beta(bs-18450R) at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 51 kD
Observed band size: 51 kD
|
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
