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Rabbit Anti-Neurotrypsin  antibody (bs-18217R)  
~~~促销代码KT202411~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-18217R
英文名称 Rabbit Anti-Neurotrypsin  antibody
中文名称 神经胰蛋白酶抗体
别    名 BSSP 3; BSSP3; Leydin; MGC12722; MOTOPSIN; MRT1; NETR_HUMAN; Neurotrypsin; protease, serine, 12 (neurotrypsin, motopsin); Prss12; Serine protease 12.  
研究领域 细胞生物  神经生物学  泛素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human)
产品应用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 95kDa
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Neurotrypsin: 401-500/875 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]

Function:
Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.

Subcellular Location:
Secreted.

Tissue Specificity:
Brain and Leydig cells of the testis.

DISEASE:
Defects in PRSS12 are the cause of mental retardation autosomal recessive type 1 (MRT1) [MIM:249500]. Mental retardation is a mental disorder characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs.

Similarity:
Belongs to the peptidase S1 family.
Contains 1 kringle domain.
Contains 1 peptidase S1 domain.
Contains 4 SRCR domains.

SWISS:
P56730

Gene ID:
8492

Database links:

 Entrez Gene: 8492 Human

Entrez Gene: 19142 Mouse

Entrez Gene: 85266 Rat

SwissProt: P56730 Human

SwissProt: O08762 Mouse

SwissProt: Q99JC8 Rat

Unigene: 445857 Human

Unigene: 9431 Mouse

Unigene: 86653 Rat



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