| 产品编号 | bs-17684R |
| 英文名称 | SPOPL |
| 中文名称 | SPOPL蛋白抗体 |
| 别 名 | HIB homolog 2; SPOPL_HUMAN; Roadkill homolog 2; Speckle type POZ protein like. |
| 研究领域 | 肿瘤 细胞生物 神经生物学 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Chicken,Pig,Cow,Horse,Rabbit) |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 45kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SPOPL: 51-150/392 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
SPOPL is a 392 amino acid nuclear protein that may be involved in ubiquitination and proteasomal degradation processes. Belonging to the Tdpoz family, SPOPL contains one BTB (POZ) domain and one MATH domain. SPOPL forms a complex with a member of the cullin family. The gene that encodes SPOPL includes 71,768 bases, four transcripts and maps to the human chromosome 2q22.1. Chromosomal arm 2q22-23 has been identified as one of fifteen hot spots thought to be involved in head and neck squamous cell carcinoma (HNSCC). Chromosome 2, which consists of 237 million bases, encodes over 1,400 genes and makes up approximately 8% of the human genome. A number of genetic diseases are linked to genes on chromosome 2 including Harlequin icthyosis, sitosterolemia and Alstr鰉 syndrome. Function: SPOPL belongs to the Tdpoz family. It contains 1 BTB (POZ) domain and 1 MATH domain. In complex with a cullin SPOPL may act in ubiquitination and proteasomal degradation processes. Subunit: Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and H2AFY. Subcellular Location: Nuclear Similarity: Belongs to the Tdpoz family. Contains 1 BTB (POZ) domain. Contains 1 MATH domain. SWISS: Q6IQ16 Gene ID: 339745 Database links: Entrez Gene: 339745 Human SwissProt: Q6IQ16 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
