| 产品编号 | bs-10515R |
| 英文名称 | SLC39A6 Rabbit pAb |
| 中文名称 | 雌激素调节蛋白LIV1/锌转运蛋白抗体 |
| 别 名 | LIV1; LIV 1; LIV-1; solute carrier family 39, member 6; solute carrier family 39(zinc transporter), member 6 isoform 1; Zinc transporter ZIP6; Zrt-and Irt-like protein 6; ZIP-6; Endoplasmic reticulum membrane-linked protein; Ermelin; S39A6_HUMAN. |
| 研究领域 | 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow,Dog,Horse) |
| 产品应用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 82 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLC39A6: 251-350/755 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
LIV-1 is expressed as two isoforms. LIV-1 is a multi-pass cell membrane protein that is 749 amino acids in length and is expressed abundantly in breast, prostate, placenta, kidney, pituitary and corpus callosum, as well as in cells derived from various types of cancers affecting the glands, cervix and lungs. LIV-1 is a member of the ZIP transporter protein family which consists of 14 members that transport zinc. LIV-1 transports zinc from its position on the plasma membrane into the cytosol of the cell and contains a histidine-rich transmembrane domain which is thought to bind zinc and aid in its transportation. LIV-1 is thought to be important for zinc uptake in neuroblastoma cells and may also be crucial for maintaining zinc homeostasis, a process which aids in the prevention of cancer and disease. Activated estrogen receptors are thought to regulate LIV-1 expression at the level of transcription, via the mRNA precursor to LIV-1 which associates with estrogen receptors that are activated by growth factors and estradiol. LIV-1 is upregulated in hormone-rich tissue, including breast and cervical cancer, where it is thought to affect cell motility and may play an important role in tumor development and metastasis. Conversely, less aggressive tumors may contain high levels of LIV-1 that could lead to apoptosis, indicating a dual role for LIV-1 in tumor suppression. Function: May act as a zinc-influx transporter. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. Post-translational modifications: N-glycosylated. Similarity: Belongs to the ZIP transporter (TC 2.A.5) family. SWISS: Q13433 Gene ID: 25800 Database links: Entrez Gene: 25800 Human Entrez Gene: 106957 Mouse Omim: 608731 Human SwissProt: Q13433 Human SwissProt: Q8C145 Mouse Unigene: 729034 Human Unigene: 21688 Mouse Unigene: 99415 Rat
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
