| 产品编号 | bs-16153R |
| 英文名称 | Rabbit Anti-FMO2 antibody |
| 中文名称 | 肝黄素单加氧酶2抗体 |
| 别 名 | 2310008D08Rik; 2310042I22Rik; AW107733; Dimethylaniline monooxygenase [N oxide forming] 2; Dimethylaniline monooxygenase [N-oxide-forming] 2; Dimethylaniline oxidase 2; Flavin containing monooxygenase 2 (non functional); Flavin containing monooxygenase 2; FLJ40826; FMO 1B1; FMO 2; FMO; FMO pulmonary; FMO1B1; FMO2; FMO2_HUMAN; MGC28212; OTTMUSP00000028686; OTTMUSP00000028687; Pulmonary flavin containing monooxygenase 2; Pulmonary flavin-containing monooxygenase 2. |
| 研究领域 | 细胞生物 免疫学 信号转导 新陈代谢 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Rabbit,Sheep,Cow,Horse,Chimpanzee) |
| 产品应用 | IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 53kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FMO2: 51-150/471 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in some human populations, this enzyme is truncated and likely degraded rapidly. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1. [provided by RefSeq, Jun 2013] Function: Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. Subcellular Location: Microsome membrane. Endoplasmic reticulum membrane. Tissue Specificity: Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. Post-translational modifications: The truncated form is probably unable to fold correctly and is rapidly degraded. FMO2*1 is sumoylated at 'Lys-492'. Similarity: Belongs to the FMO family. SWISS: Q99518 Gene ID: 2327 Database links: Entrez Gene: 2327 Human Entrez Gene: 55990 Mouse Entrez Gene: 100171693 Orangutan Entrez Gene: 703639 Rhesus monkey Omim: 603955 Human SwissProt: Q8HZ70 Chimpanzee SwissProt: Q8HZ69 Gorilla SwissProt: P36366 Guinea pig SwissProt: Q99518 Human SwissProt: Q8K2I3 Mouse SwissProt: Q5REK0 Orangutan SwissProt: Q28505 Rhesus monkey Unigene: 144912 Human Unigene: 10929 Mouse |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
