| 产品编号 | bs-14403R |
| 英文名称 | DOCK10 Rabbit pAb |
| 中文名称 | DOCK10蛋白抗体 |
| 别 名 | 9330153B10Rik; A630054M16Rik; dedicator of cytokinesis 10; Dedicator of cytokinesis protein 10; DKFZp781A1532; DRIP2; Jr4; Jr5; KIAA0694; MGC183664; mKIAA0694; Nbla10300; R75174; ZIZ3; Zizimin 3. |
| 研究领域 | 细胞生物 信号转导 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Pig) |
| 产品应用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 250 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DOCK10: 4-100/186 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
DOCK 10 is a 2,183 amino acid protein that belongs to the DOCK family of cytokinesis-regulating proteins and cotnains one PH domain, one DHR-1 domain and one DHR-2 domain. Expressed at lower levels in lung and brain tissue, DOCK 10 functions as a potential GEF (guanine nucleotide exchange factor) that is able to activate target GTPases by exchanging bound GDP for free GTP. Multiple isoforms of DOCK 10 exist due to alternative splicing events. The gene encoding DOCK 10 maps to human chromosome 2, which houses over 1,400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, Alstr鰉 syndrome, is caused by mutations in the ALMS1 gene, which maps to chromosome 2. Function: DOCK10 is a potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Two named isoforms exist, produced by alternative splicing. Tissue Specificity: Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells. Similarity: Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Contains 1 PH domain. SWISS: Q96BY6 Gene ID: 55619 Database links: Entrez Gene: 55619 Human Omim: 611518 Human SwissProt: Q96BY6 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
