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ADRA1B Rabbit pAb (bs-10465R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-10465R
英文名称 ADRA1B Rabbit pAb
中文名称 alpha 1肾上腺素能受体B抗体
别    名 ADA1B_HUMAN; ADRA1; ALPHA1BAR; alpha-1B adrenergic receptor; alpha-1B adrenoreceptor; alpha-1B adrenoceptor; alpha-1B-adrenergic receptor; adrenergic, alpha-1B-, receptor.  
研究领域 神经生物学  通道蛋白  G蛋白偶联受体  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Mouse (predicted: Human,Rat,Rabbit,Pig,Sheep,Cow,Chicken,Dog,GuineaPig,Horse)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 57 kDa
检测分子量
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ADRA1B: 1-100/520 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region. [provided by RefSeq, Jul 2008].

Function:
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

Subunit:
Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes.

Subcellular Location:
Nucleus membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.

Similarity:
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.

SWISS:
P35368

Gene ID:
147

Database links:

Entrez Gene: 147 Human

Entrez Gene: 11548 Mouse

Entrez Gene: 24173 Rat

Omim: 104220 Human

SwissProt: P35368 Human

SwissProt: P97717 Mouse

SwissProt: P15823 Rat

Unigene: 368632 Human

Unigene: 39086 Mouse

Unigene: 10032 Rat



产品图片
Sample: Liver (Mouse) Lysate at 40 ug Primary: Anti-ADRA1B (bs-10465R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 57kD Observed band size: 60kD
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