产品编号 | bs-10407R |
英文名称 | Rabbit Anti-Thrombopoietin antibody |
中文名称 | 血小板生成素/巨核细胞集落刺激因子抗体 |
别 名 | c mpl ligand; C-mpl ligand; Megakaryocyte Colony Stimulating Factor; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; Megakaryocyte stimulating factor; MGDF; MKCSF; ML; MPL ligand; MPLLG; Myeloproliferative Leukemia Virus Oncogene Ligand; THPO; Thrombopoietin; Thrombopoietin nirs variant 1; TPO; TPO_HUMAN. |
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Specific References (1) | bs-10407R has been referenced in 1 publications.
[IF=12.52] Nakamura-Ishizu, Ayako, et al. "CLEC-2 in megakaryocytes is critical for maintenance of hematopoietic stem cells in the bone marrow." The Journal of experimental medicine (2015): jem-20150057. IHC-F ; Mouse.
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研究领域 | 肿瘤 心血管 细胞生物 干细胞 细胞周期蛋白 细胞分化 |
抗体来源 | Rabbit |
克隆类型 | Polyclonal |
交叉反应 | Human,Mouse,Rat (predicted: Sheep,Cow) |
产品应用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
理论分子量 | 37kDa |
细胞定位 | 分泌型蛋白 |
性 状 | Liquid |
浓 度 | 1mg/ml |
免 疫 原 | KLH conjugated synthetic peptide derived from human Thrombopoietin: 21-120/353 |
亚 型 | IgG |
纯化方法 | affinity purified by Protein A |
缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
PubMed | PubMed |
产品介绍 |
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.[provided by RefSeq, Jun 2012]. Function: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Subcellular Location: Secreted. DISEASE: Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the EPO/TPO family. SWISS: P40225 Gene ID: 7066 Database links: Entrez Gene: 7066 Human Entrez Gene: 21832 Mouse Omim: 600044 Human SwissProt: P40225 Human SwissProt: P40226 Mouse Unigene: 1166 Human Unigene: 3943 Mouse Unigene: 10576 Rat |
产品图片 | |
1、抗体溶解方法 | |
2、抗体修复方式 | |
3、常用试剂的配制 | |
4、免疫组化操作步骤 | |
5、免疫组化问题解答 | |
6、Western Blotting 操作步骤 | |
7、Western Blotting 问题解答 | |
8、关于肽链的设计 | |
9、多肽的溶解与保存 | |
10、酶标抗体效价测定程序 | |