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GPR26 Rabbit pAb (bs-13527R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-13527R
英文名称 GPR26 Rabbit pAb
中文名称 G蛋白偶联受体26抗体
别    名 AXOR49; DKFZp761H2121; FLJ33774; G protein-coupled receptor 26; G protein-coupled receptor 26; G protein-coupled receptor GPR26; MGC138216; GPR26_HUMAN; GPCR GPR26.  
研究领域 细胞生物  神经生物学  信号转导  G蛋白偶联受体  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Dog,Horse)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 38 kDa
检测分子量
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human G protein-coupled receptor 26: 101-200/337 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intracellular signal (G protein activation). GPR signaling is an ancient evolutionarily mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. GPRs have seven membrane-spanning domains and the extracellular domains are often glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR26 (G-protein coupled receptor 26) is a 337 amino acid protein that is primarily expressed in regions of the brain. GPR26 is characterized as an ‘orphan’ G protein-coupled receptor, which is a receptor that binds an unidentified natural ligand. Due to evidence of GPR26 being downregulated in glioblastomas, it has been suggested that GPR26 may be a suppressor of early glioma development.

Function:
GPCR GPR26 is an Orphan receptor. It displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. Is highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Tissue Specificity:
Highly expressed in the CNS, the highest expression is seen in the amygdala, hippocampus and thalamus. Weak expression is detected in testis. Down-regulated in glioblastoma.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
Q8NDV2

Gene ID:
2849

Database links:

Entrez Gene: 2849 Human

Entrez Gene: 233919 Mouse

Entrez Gene: 192153 Rat

Omim: 604847 Human

SwissProt: Q8NDV2 Human

SwissProt: Q8BZA7 Mouse

SwissProt: Q9QXI3 Rat

Unigene: 12751 Human

Unigene: 208740 Mouse

Unigene: 48779 Rat



产品图片
Sample: Jurkat(Human) Cell Lysate at 30 ug Primary: Anti-GPR26 (bs-13527R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 38 kD Observed band size: 34 kD
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