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Rabbit Anti-FCGRT  antibody (bs-13151R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-13151R
英文名称 FCGRT
中文名称 IgG-Fc片断受体转运蛋白α抗体
别    名 IgG receptor FcRn large subunit p51; Fc fragment of IgG, receptor transporter, alpha; FCGRT; FcRn alpha chain; FCRN; FCRN, alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG Gc receptor; IgG receptor FcRn large subunit p51 precursor; Immunoglobulin receptor, intestinal, heavy chain; Neonatal Fc receptor; FCGRN_HUMAN.  
Specific References  (1)     |     bs-13151R has been referenced in 1 publications.
[IF=1.64] Zhang, Wang-Dong, et al. "Localization of neonatal Fc receptor for IgG in aggregated lymphoid nodules area in abomasum of Bactrian camels (Camelus bactrianus) of different ages." BMC Veterinary Research 12.1 (2016): 237.  IHC-P ;  Others.  
研究领域 细胞生物  免疫学  细胞膜受体  血管内皮细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Mouse (predicted: Rat,Dog,Sheep)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, ICC=1:100-500, IF=1:100-500, Flow-Cyt=3μg/Test, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 37kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FCGRT/FcRn: 51-150/365 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.

Function:
Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus.

Subunit:
FcRn complex consist of two subunits: p51, and p14 which is equivalent to beta-2-microglobulin. It forms an MHC class I-like heterodimer (By similarity).

Subcellular Location:
Cell membrane.

Similarity:
Belongs to the immunoglobulin superfamily.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

SWISS:
P55899

Gene ID:
2217

Database links:

Entrez Gene: 2217 Human

Omim: 601437 Human

SwissProt: P55899 Human

Unigene: 111903 Human



产品图片
Sample: bladder (Mouse)Lysate at 40 ug
Primary: Anti-FCGRT(bs-13151R)at 1/300 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 38kD
Observed band size: 38 kD
Blank control(blue): U-87MG(fixed with 2% paraformaldehyde (10 min)).
Primary Antibody:Rabbit AntiFCGRT antibody(bs-13151R), Dilution: 3μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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