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EPS15R Rabbit pAb (bs-13100R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-13100R
英文名称 EPS15R Rabbit pAb
中文名称 表皮生长因子受体底物15抗体
别    名 epidermal growth factor receptor pathway substrate 15-ike 1; Epidermal growth factor receptor substrate 15 like 1; epidermal growth factor receptor substrate EPS15R; Eps15 related protein; eps15R; EP15R_HUMAN.  
研究领域 细胞生物  生长因子和激素  激酶和磷酸酶  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 (predicted: Human,Mouse,Rat,Rabbit,Pig,Sheep,Cow,Dog,Horse)
产品应用 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 94 kDa
检测分子量
细胞定位 细胞核 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EPS15R: 275-380/864 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation, as miscues in RTK signaling can result in cellular transformation events that may ultimately lead to cancer. Eps15 (EGF-receptor pathway substrate 15) is an EGF receptor substrate that become become tyrosine phosphorylated subsequent to EGF stimulation. Over expression of Eps15 in NIH/3T3 cells causes cellular transformation, implying involvement of Eps15 in the regulation of cell proliferation. Eps15R (Eps15-related), also known as Eps15L1 (epidermal growth factor receptor substrate 15-like 1), is an 864 amino acid protein that contains one EF-hand domain and three EH domains. Localized to a variety of places within the cell, including the nucleus, cytoplasm and membrane-coated pits, Eps15R is thought to function as a component of clathrin-coated pits. Like Eps15, Eps15R may play an important role in receptor-mediated endocytosis.

Function:
EPS15 and EPS15R are substrates of the epidermal growth factor (EGF) receptor kinase, which are characterized by their ability to bind to the clathrin adaptor protein complex adaptor protein 2, and the presence of a protein:protein interaction domain, the EH domain. Evidence suggests that EPS15 and EPS15R are involved in endocytosis. The major difference between these two related proteins is that EPS15R is also found in the nucleus, whereas EPS15 is excluded from this compartment at steady state.

Subunit:
Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2) (By similarity). Interacts with FCHO1. Interacts with FCHO2. Interacts (via EH domains) with DAB2.

Subcellular Location:
Cell Membrane and Nuclear.

Post-translational modifications:
Phosphorylated on tyrosine residues by EGFR (By similarity).

Similarity:
Contains 1 EF-hand domain.
Contains 3 EH domains.

SWISS:
Q9UBC2

Gene ID:
58513

Database links:

Entrez Gene: 58513 Human

Omim: 600051 Human

SwissProt: Q9UBC2 Human

Unigene: 654639 Human

Unigene: 744842 Human



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