| 产品编号 | bs-12125R |
| 英文名称 | SLC38A2 |
| 中文名称 | 氨基酸转运蛋白2抗体 |
| 别 名 | Amino acid transporter 2; Amino acid transporter A2; ATA2; SNAT2; KIAA1382; PRO1068; Protein 40-9-1; S38A2_HUMAN; SAT2; Slc38a2; Sodium-coupled neutral amino acid transporter 2; Solute carrier family 38 member 2; System A amino acid transporter; System A amino acid transporter 2; System A transporter 1; System N amino acid transporter 2. |
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Specific References (3) | bs-12125R has been referenced in 3 publications.
[IF=16.174] Zhao Xiaohui. et al. Chemoproteomics reveals microbiota-derived aromatic monoamine agonists for GPRC5A. NAT CHEM BIOL. 2023 May;:1-10 WB ; Human.
[IF=5.076] Hu C et al. Placentae for Low Birth Weight Piglets Are Vulnerable to Oxidative Stress, Mitochondrial Dysfunction, and Impaired Angiogenesis. Oxid Med Cell Longev. 2020 May 25;2020:8715412. WB ; Pig.
[IF=3.478] Jan Remsik. et al. Characterization, isolation and in vitro culture of leptomeningeal fibroblasts. J Neuroimmunol. 2021 Sep;:577727 IF ; mouse .
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| 研究领域 | 神经生物学 通道蛋白 细胞膜受体 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Rat,Mouse (predicted: Sheep,Horse,Cow,Pig,Dog,Human) |
| 产品应用 | WB=1:500-2000, IHC-F=1:100-500, IF=1:100-500, ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 56kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SLC38A2/SNAT2: 21-150/506 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The sodium-coupled neutral amino acid transporters (SNAT) of the SLC38 gene family include System A subtypes SNAT1, SNAT2 and SNAT4 and System N subtypes SNAT3 and SNAT5. The SLC38 transporters are essential for the uptake of nutrients, energy production, metabolism, detoxification, and the cycling of neurotransmitters. SNAT2, also designated ATA2, PRO1068 and SAT2 is encoded by the human gene SLC38A2. The functional role of SNAT2 in the nervous system is unclear. Protein expression is notably enriched in the spinal cord and brain stem nuclei of the auditory system. System A transport proteins are also present in placental tissue. These SNAT proteins may play a significant role in fetal development and inhibition of the transport system has been associated with fetal growth retardation. Function: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta. Subcellular Location: Cell membrane. Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes. Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal. Tissue Specificity: Ubiquitously expressed. Widely expressed in the central nervous system with higher concentrations in caudal regions. Expressed by glutamatergic and GABAergic neurons together with astrocytes and other non-neuronal cells in the cerebral cortex (at protein level). Post-translational modifications: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. Similarity: Belongs to the amino acid/polyamine transporter 2 family. SWISS: Q96QD8 Gene ID: 112483 Database links: Entrez Gene: 54407 Human Entrez Gene: 67760 Mouse Omim: 605180 Human SwissProt: Q96QD8 Human SwissProt: Q8CFE6 Mouse Unigene: 221847 Human Unigene: 46754 Mouse Unigene: 16393 Rat |
| 产品图片 |
Sample:
Lane 1: Mouse Liver tissue lysates Lane 2: Rat Lung tissue lysates Primary: Anti-SLC38A2 (bs-12125R) at 1/200 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 56 kDa Observed band size: 60 kDa |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
