| 产品编号 | bs-11532R |
| 英文名称 | PTPRN Rabbit pAb |
| 中文名称 | 蛋白酪氨酸磷酸酶样N前体蛋白抗体 |
| 别 名 | IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N; PTP IA-2; mIA-A; mKIAA4064; BEM-3; ICA105; PTPLP; PTPRN_BOVIN; PTPRN; Islet cell autoantigen 512 (ICA512); PTPRN_HUMAN; Islet cell antigen 512 (ICA 512); Islet cell autoantigen 3; ICA3; PTPRN_MOUSE; Ptp35; PTPRN_RAT; |
| 研究领域 | 肿瘤 神经生物学 信号转导 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Rat (predicted: Human,Mouse,Pig,Sheep,Cow) |
| 产品应用 | Flow-Cyt=3μg/Test
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 102 kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TPIA2: 501-600/979 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010] Function: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Subunit: Interacts with phosphorylated SNTB2, protecting it from protein cleavage by CAPN1. Dephosphorylation of SNTB2 upon insulin stimulation disrupts the interaction and results in its cleavage. Subcellular Location: Membrane. Neuroendocrine secretory granules. Tissue Specificity: Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. Post-translational modifications: Appears to undergo multiple proteolytic cleavage at consecutive basic residues. Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. Contains 1 tyrosine-protein phosphatase domain. SWISS: Q16849 Gene ID: 5798 Database links: Entrez Gene: 5798 Human Entrez Gene: 19275 Mouse Omim: 601773 Human SwissProt: Q16849 Human SwissProt: Q60673 Mouse Unigene: 89655 Human Unigene: 2902 Mouse Unigene: 11097 Rat |
| 产品图片 |
Positive control: RSC96
Isotype Control Antibody: Rabbit IgG ;
Secondary Antibody: Goat anti-rabbit IgG-FITC,
Dilution: 1:100 in 1 X PBS containing 0.5% BSA ;
Primary Antibody Dilution: 3μg in 100 μL1X PBS containing 0.5% BSA.
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
