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Rabbit Anti-PLXNB3  antibody (bs-11470R)  
~~~促销,代码KT202502A~~~
~~~促销,代码KT202502B~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-11470R
英文名称 Rabbit Anti-PLXNB3  antibody
中文名称 神经丛蛋白B3抗体
别    名 Plexin B3; KIAA1206; PLEXB3; Plexin-B3; PLEXR; PLXB3_HUMAN; PLXN6; PLXNB3.  
研究领域 细胞生物  神经生物学  细胞分化  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse (predicted: Human,Rat,Pig,Dog,Horse)
产品应用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 202kDa
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Plexin B3: 354-400/1909 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Plexins are a family of large, transmembrane receptors for multiple classes of semaphorins in vertebrates. They are widely expressed, and regions of their extracellular domain are homologus to both scatter factor receptors and semaphorin domains. Plexins may act as semaphorin receptors alone or in combination with neuropilins. Plexins are divided into four subfamilies designated plexin-A, -B, -C, and -D. Plexin-B1 and -B2 are both receptors for Sema4D, which stimulates axonal outgrowth of embryonic dorsal root ganglion neurons. . Plexin-B3 binds to Sema5A, which controls axon guidance and can initiate the intracellular signaling of the hepatocyte growth factor/scatter factor receptor Met.

Function:
Receptor for SEMA5A. Plays a role in axon guidance, invasive growth and cell migration.

Subunit:
Interacts (via cytoplasmic domain) with RAC1 and ARHGDIA (By similarity). Binds MET and MST1R. Interacts (via cytoplasmic domain) with FSCN1. Interacts with RIT2/RIN. May form homodimers (via Sema domain).

Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Note=Colocalizes with RIT2/RIN at the plasma membrane.

Tissue Specificity:
Detected at very low levels in several fetal tissues.

Similarity:
Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.

SWISS:
Q9ULL4

Gene ID:
5365

Database links:

Entrez Gene: 5365 Human

Omim: 300214 Human

SwissProt: Q9ULL4 Human

Unigene: 632833 Human



产品图片
Paraformaldehyde-fixed, paraffin embedded (Mouse cerebellum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PLXNB3) Polyclonal Antibody, Unconjugated (bs-11470R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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