| 产品编号 | bs-9477R |
| 英文名称 | CMYA2/PDE4DIP Rabbit pAb |
| 中文名称 | 心肌病相关蛋白2抗体 |
| 别 名 | Cardiomyopathy associated protein 2; Cardiomyopathy-associated protein 2; CMYA2; MMGL; MYOME_HUMAN; Myomegalin; Pde4dip; phosphodiesterase 4D interacting protein; phosphodiesterase 4D-interacting protein. |
| 研究领域 | 心血管 信号转导 细胞骨架 细胞外基质 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse) |
| 产品应用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ICC/IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 265 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP: 1501-1600/2365 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes.
Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events. Function: May function as an anchor sequestering components of thecAMP-dependent pathway to Golgi and/or centrosomes (By similarity). Subunit: Interacts with PDE4D (By similarity). Subcellular Location: Golgi apparatus (By similarity). Cytoplasm,cytoskeleton, centrosome (By similarity). Cytoplasm. Nucleus. Tissue Specificity: Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta. DISEASE: Note=A chromosomal aberration involving PDE4DIP may bethe cause of a myeloproliferative disorder (MBD) associated witheosinophilia. Translocation t(1;5)(q23;q33) that forms aPDE4DIP-PDGFRB fusion protein. Similarity: Contains 1 NBPF domain. SWISS: Q5VU43 Gene ID: 9659 Database links: Entrez Gene: 9659 Human Entrez Gene: 83679 Mouse Omim: 608117 Human SwissProt: Q5VU43 Human SwissProt: Q80YT7 Mouse Unigene: 584841 Human Unigene: 613082 Human Unigene: 657490 Human Unigene: 728768 Human Unigene: 129840 Mouse Unigene: 48693 Rat |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
