| 产品编号 | bs-8291R |
| 英文名称 | DPY19L2 Rabbit pAb |
| 中文名称 | DPY19L2蛋白抗体 |
| 别 名 | D19L2_HUMAN; Probable C-mannosyltransferase DPY19L2; dpy 19 like 2; dpy 19 like 2(C. elegans); Dpy 19 like protein 2; Dpy-19-like protein 2; dpy19; FLJ32949; FLJ36166; Protein dpy 19 homolog 2; Protein dpy-19 homolog 2. |
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Specific References (4) | bs-8291R has been referenced in 4 publications.
[IF=11.043] Chunyu Liu. et al. Deficiency of primate-specific SSX1 induced asthenoteratozoospermia in infertile men and cynomolgus monkey and tree shrew models. AM J HUM GENET. 2023 Feb 15 WB ; Human,Monkey.
[IF=9.621] Lixiao Zhou. et al. Repression of autophagy leads to acrosome biogenesis disruption caused by a sub-chronic oral administration of polystyrene nanoparticles. Environ Int. 2022 May;163:107220 WB ; Mouse.
[IF=6.918] Li Yaqian. et al. Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects. Hum Reprod. 2021 Nov;: IF ; Mouse,Human.
[IF=5.589] WB ; mouse.
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| 研究领域 | 细胞生物 免疫学 发育生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Mouse (predicted: Human,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 产品应用 | WB=1:500-2000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 87 kDa |
| 检测分子量 | |
| 细胞定位 | 细胞膜 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human DPY19L2: 101-200/758 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
The protein encoded by this gene belongs to the dpy-19 family. It is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9). [provided by RefSeq, Dec 2011] Function: Required during spermatogenesis for sperm head elongation and acrosome formation. Subunit: Membrane; Multi-pass membrane protein (Potential). Subcellular Location: Involvement in disease：Defects in DPY19L2 are a cause of globozoospermia (GLOBZOOS) . An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome. In the most severe cases the acrosome is totally absent. Globozoospermia is also characterized by abnormal nuclear shape as well as abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of GLOBZOOS. Tissue Specificity: Widely expressed with high expression in testis. DISEASE: Defects in DPY19L2 are the cause of spermatogenic failure type 9 (SPGF9) [MIM:613958]. An infertility disorder caused by spermatogenesis defects. The most prominent feature is the malformation of the acrosome, which can be totally absent in most severe cases. Additional features are an abnormal nuclear shape and abnormal arrangement of the mitochondria of the spermatozoon. Note=Deletions in DPY19L2 are probably the major cause of SPGF9. Similarity: Belongs to the dpy-19 family. SWISS: Q6NUT2 Gene ID: 283417 Database links: Entrez Gene: 283417 Human Entrez Gene: 320752 Mouse SwissProt: Q6NUT2 Human SwissProt: P0CW70 Mouse Unigene: 533644 Human |
| 产品图片 |
Sample:
Lane 1: Mouse Testis tissue lysates
Primary: Anti-DPY19L2 (bs-8291R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 87 kDa
Observed band size: 77 kDa
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
