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MDM2BP Rabbit pAb (bs-6388R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-6388R
英文名称 MDM2BP Rabbit pAb
中文名称 双微体2癌基因结合蛋白抗体
别    名 MDM 2 binding protein; MDM 2 BP; MDM2(mouse double minute 2) binding protein 104kD; MDM2(mouse double minute 2) binding protein; MDM2 binding protein; MDM2 BP; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein(mouse) binding protein 104kDa; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein(mouse) binding protein; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein; MDM2BP; Mouse double minute 2 homolog binding protein; MTBP_HUMAN.  
研究领域 肿瘤  细胞生物  染色质和核信号  细胞周期蛋白  表观遗传学  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human,Mouse (predicted: Rat,Pig,Sheep,Cow,Chicken,Dog,Horse)
产品应用 IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 102 kDa
检测分子量
细胞定位 细胞核 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MTBP/MDM2BP: 821-904/904 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation.

Function:
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.

Subunit:
Interacts with MDM2.

Similarity:
Belongs to the MTBP family.

SWISS:
Q96DY7

Gene ID:
27085

Database links:

Entrez Gene: 27085 Human

Entrez Gene: 105837 Mouse

Omim: 605927 Human

SwissProt: Q96DY7 Human

SwissProt: Q80VU3 Mouse

SwissProt: Q8BJS8 Mouse

SwissProt: Q8BTU9 Mouse

SwissProt: Q8BTW0 Mouse

SwissProt: Q9ER61 Mouse

Unigene: 186433 Human

Unigene: 46701 Human

Unigene: 61901 Mouse



产品图片
Paraformaldehyde-fixed, paraffin embedded (mouse ovary); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MDM2BP) Polyclonal Antibody, Unconjugated (bs-6388R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
Paraformaldehyde-fixed, paraffin embedded (human breast carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MDM2BP) Polyclonal Antibody, Unconjugated (bs-6388R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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