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Rabbit Anti-Klrb1c  antibody (bs-4682R)  
~~~促销代码KT202411~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-4682R
英文名称 Rabbit Anti-Klrb1c  antibody
中文名称 NKR-P1C(NK1.1)抗体
别    名 Killer cell lectin-like receptor subfamily B member 1C; Killer cell lectin-like receptor subfamily B member 1; CD161 antigen-like family member C; Lymphocyte antigen 55c; Ly-55c; NK1.1; NKR-P1.9; NKR-P1C; Natural killer cell surface protein P1-40; NKR-P1 40; CD161c; Ly55c; Nkrp1c; KLRBC_MOUSE;   
Specific References  (7)     |     bs-4682R has been referenced in 7 publications.
[IF=17.694] Kim, Hyun-Jin. et al. Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma. NAT COMMUN. 2022 Oct;13(1):1-14  IHC ;  Mouse.  
[IF=7.56] Cheekatla, Satyanarayana Swamy, et al. "NK-CD11c+ Cell Crosstalk in Diabetes Enhances IL-6-Mediated Inflammation during Mycobacterium tuberculosis Infection." PLoS Pathog 12.10 (2016): e1005972.  IHC-P ;  Mouse.  
[IF=6.107] Leimbacher Aurelia C.. et al. Voluntary Exercise Does Not Always Suppress Lung Cancer Progression. ISCIENCE. 2023 Jan 31  IHC ;  Mouse.  
[IF=3.478] Liu G et al. B-cell leukemia/lymphoma 11 promotes angiogenesis in an experimental corneal neovascularization model. Eye,2018 32(7), 1220–1232.  IF ;  Mouse.  
[IF=2.388] Ina Bähr. et al. Characterization of natural killer cells in colorectal tumor tissue of rats fed a control diet or a high-fat diet. Ann Anat. 2021 Jan;233:151586  IHC ;  Rat.  
[IF=2.28] Liu et al. B-cell leukemia/lymphoma 10 promotes angiogenesis in an experimental corneal neovascularization model. (2018) Eye.(Lond).  IF(ICC) ;  Mouse.  
[IF=0] Uchida T et al. Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD56+ T cells.Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F618-F627.  IHF-P ;  Mouse.  
研究领域 免疫学  干细胞  细胞类型标志物  自然杀伤细胞  淋巴细胞  t-淋巴细胞  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,Rat (predicted: Human)
产品应用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 25kDa
检测分子量 40-48
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouse CD161c/NK1.1: 101-200/223 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within natural killer cell activation and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in thymus primordium. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Nov 2021]

Function:
Plays a stimulatory role on natural killer (NK) cells cytotoxicity. Activation by cross-linking of the receptor induces Ca(2+) mobilization and interferon-gamma production.

Subunit:
Homodimer; disulfide-linked. Interacts with tyrosine kinase LCK.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Tissue Specificity:
Expressed in natural killer cells.

SWISS:
P27814

Gene ID:
17059

Database links:

Entrez Gene: 17059 Mouse

Entrez Gene: 362443 Rat

SwissProt: P27814 Mouse

SwissProt: Q0ZUP0 Rat



产品图片
Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Thymus tissue lysates Lane 3: Mouse Lung tissue lysates Lane 4: Mouse Liver tissue lysates Lane 5: Rat Thymus tissue lysates Lane 6: Rat Liver tissue lysates Primary: Anti-Klrb1 (bs-4682R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 25 kDa Observed band size: 48 kDa
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