产品中心-北京博奥森生物技术有限公司

产品编号	bs-6700R
英文名称	SRD5A2 Rabbit pAb
中文名称	类固醇5α还原酶2抗体
别名	5 alpha SR2; EC; SR type 2; Steroid 5 alpha reductase 2; 3 oxo 5 alpha steroid 4 dehydrogenase 2; 3-oxo-5-alpha-steroid 4-dehydrogenase 2; 5 alpha-SR2; 5ART2; e II 5 alpha reductase; EC; MGC138457; Micropenis, included; S5A2_HUMAN; S5AR 2; SR type 2; SRD5A2; Steroid 5 alpha reductase 2; Steroid 5-alpha-reductase 2; Steroid-5-alpha-reductase, alpha polypeptide 2(3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2); Type II 5-alpha reductase.
	Specific References (10) \| bs-6700R has been referenced in 10 publications. [IF=4.292] Longfei Xiao. et al. Dihydrotestosterone regulation of cyclooxygenase-2 expression in bovine endometrial epithelium cells by androgen receptor mediated EGFR/PI3K/Akt pathway. J Steroid Biochem. 2021 Nov;214:106001 WB,IHC ; Bovine. PubMed:10.1016/j.jsbmb.2021.106001 [IF=4.292] Longfei Xiao. et al. Dihydrotestosterone through blockade of TGF-β/Smad signaling mediates the anti-fibrosis effect under hypoxia in canine Sertoli cells. J Steroid Biochem. 2022 Feb;216:106041 WB ; Dog. PubMed:34864206 [IF=4.24] Tanaka, Sota, et al. "The role of 5α-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma." Molecular and Cellular Endocrinology (2014). IHC-P ; Human. PubMed:25475427 [IF=3.659] Lu, Shan. et al. An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification. Bmc Complem Altern M. 2022 Dec;22(1):1-20 WB ; Human. PubMed:35236335 [IF=3.415] Kumata H et al. Steroidogenesis in ovarian‐like mesenchymal stroma of hepatic and pancreatic mucinous cystic neoplasms.Hepatol Res. 2018 Nov;48(12):989-999. IHC-P ; Human. PubMed:29882386 [IF=2.984] Junjie Hu. et al. Assessment of progesterone synthesis and its regulation role on dihydrotestosterone secretion in sheep epididymis. Gene. 2021 Jul;790:145699 WB ; Sheep. PubMed:33964380 [IF=2.923] Hongwei Duan. et al. Melatonin regulates dihydrotestosterone formation via its membrane receptor in the epididymal epithelial cells of sheep. THERIOGENOLOGY. 2022 Dec;: WB ; Sheep. PubMed:36623430 [IF=2.775] Binghao Bao. et al. Zuogui Wan improves spermatogenesis of GC1-spg cells through modulating AR-related pathways. ANDROLOGIA. 2022 Apr 08 WB ; Mouse. PubMed:10.1111/and.14407 [IF=2.445] Song L et al. DHT and E2 synthesis-related proteins and receptors expression in male yak skin during different hair follicle stages. Gen Comp Endocrinol. 2019 Aug 12:113245. WB&IHC-P ; Yak. PubMed:31415730 [IF=1.951] Jisheng Wang. et al. In vitro and in vivo investigation of the therapeutic mechanism of Lycium Chinense and Cuscutae Semen on oligoasthenozoospermia. 2021 Mar 05 WB ; Rat. PubMed:33666949
研究领域	细胞生物信号转导细胞凋亡细胞周期蛋白转录调节因子
抗体来源	Rabbit
克隆类型	Polyclonal
克隆号
交叉反应	(predicted: Human,Mouse,Rat,Pig,Horse)
产品应用	IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理论分子量	28 kDa
检测分子量
细胞定位	细胞浆细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human SRD5A2: 201-254/254
亚型	IgG
纯化方法	affinity purified by Protein A
缓冲液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
产品介绍	Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Function: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Subcellular Location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Tissue Specificity: Expressed in high levels in the prostate and many other androgen-sensitive tissues. DISEASE: Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH) [MIM:264600]. A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. Similarity: Belongs to the steroid 5-alpha reductase family. SWISS: P31213 Gene ID: 6716 Database links: Entrez Gene: 403715 Dog Entrez Gene: 6716 Human Entrez Gene: 94224 Mouse Entrez Gene: 397048 Pig Entrez Gene: 64677 Rat Omim: 607306 Human SwissProt: P31213 Human SwissProt: Q3UTZ9 Mouse SwissProt: Q99N99 Mouse SwissProt: O18765 Pig SwissProt: P31214 Rat Unigene: 458345 Human Unigene: 38933 Mouse Unigene: 9938 Rat

	免疫组化常用试剂
	免疫印迹常用试剂
	各种标记二抗

	1、抗体溶解方法
	2、抗体修复方式
	3、常用试剂的配制
	4、免疫组化操作步骤
	5、免疫组化问题解答
	6、Western Blotting 操作步骤
	7、Western Blotting 问题解答
	8、关于肽链的设计
	9、多肽的溶解与保存
	10、酶标抗体效价测定程序

	AbBy Fluor 350 标记
	AbBy Fluor 488 标记
	AbBy Fluor 555 标记
	AbBy Fluor 594 标记
	AbBy Fluor 647 标记
	AP 标记
	APC 标记
	Biotin 标记
	Cy3 标记
	Cy5 标记
	Cy5.5 标记
	Cy7 标记
	FITC 标记
	Gold 标记
	HRP 标记
	PE 标记
	PE-Cy3 标记
	PE-CY5 标记
	PE-CY5.5 标记
	PE-CY7 标记
	RBITC 标记