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phospho-HRH1 (Ser398) Rabbit pAb (bs-6665R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-6665R
英文名称 phospho-HRH1 (Ser398) Rabbit pAb
中文名称 磷酸化组胺受体H1抗体
别    名 HRH1(phospho S398); p-HRH1(phospho Ser398); HRH1(phospho S398); H1R; HisH1; Histamine H1 receptor; Histamine receptor H1; Histamine receptor subclass H1.  
产品类型 磷酸化抗体 
研究领域 细胞生物  信号转导  生长因子和激素  转录调节因子  G蛋白偶联受体  G蛋白信号  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Mouse,Rabbit (predicted: Human,Rat,Pig,Cow,Dog,GuineaPig,Horse)
产品应用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 54 kDa
检测分子量
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human HRH1 around the phosphorylation site of Ser398: SH(p-S)RQ 
亚    型
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].

Function:
In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

Subcellular Location:
Cell membrane; Multi-pass membrane protein.

Post-translational modifications:
Potential sites of phosphorylation in the third cytoplasmic loop may play an important role in regulating signal transduction through the receptor molecule.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

SWISS:
P35367

Gene ID:
3269

Database links:

Entrez Gene: 3269 Human

Entrez Gene: 15465 Mouse

Omim: 600167 Human

SwissProt: P35367 Human

SwissProt: P70174 Mouse

Unigene: 1570 Human

Unigene: 333327 Mouse



产品图片
Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-phospho-HRH1(Ser398) (bs-6665R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kD Observed band size: 55 kD
phosphopeptide non phosphopeptide
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