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Rabbit Anti-Thyroid hormone receptor alpha  antibody (bs-6221R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-6221R
英文名称 Thyroid hormone receptor alpha
中文名称 甲状腺激素受体α抗体
别    名 AR7; c-erbA-1; C-erbA-alpha; CHNG6; EAR 7; EAR-7; EAR7; ERB-T-1; ERBA alpha; ERBA; ERBA Related 7; ERBA-related 7; ERBA1; NR1A1; Nuclear receptor subfamily 1 group A member 1; THA_HUMAN; THRA 1; THRA; THRA1; THRA2; Thyroid hormone receptor alpha; thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian); thyroid normone nuclear receptor alpha variant 1; triiodothyronine receptor; V-erbA-related protein 7.  
Specific References  (2)     |     bs-6221R has been referenced in 2 publications.
[IF=6.268] Custodio, Raly James Perez. et al. Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein. Commun Biol. 2021 Sep;4(1):1-14  WB ;  mouse.  
[IF=1.84] Sun, Yan, et al. "Thyroid hormone inhibits the proliferation of piglet Sertoli cell via PI3K signaling pathway." Theriogenology (2014).  WB ;  
研究领域 细胞生物  神经生物学  信号转导  生长因子和激素  内分泌病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Mouse,Rat (predicted: Chicken,Pig,Horse,Rabbit,Sheep,GuineaPig)
产品应用 WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1ug/Test, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 55kDa
细胞定位 细胞核 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Thyroid hormone receptor alpha: 81-180/490 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Thyroid hormone receptors (TR) are ligand dependent, intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences called hormone response elements following activation by the appropriate hormone. Thyroid hormones, through their interaction with TR, effect metabolic processes, growth and development in many tissues by regulating the expression of genes for growth hormone, malic enzyme and several hepatic proteins. There are two forms of TR; TR alpha (on chromosome 17) and TR beta (on chromosome 3). Each of these isoforms also has two isoforms; TR alpha 1 and TR alpha 2, and TR beta 1 and TR beta 2 respectively. TR alpha 1 and 2 are identical through amino acid 370, where their sequences diverge. TR alpha 2, which does not bind T3 and is a strong negative regulator of the functional TR, is 80 amino acids longer than TR alpha 1.

Function:
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Subunit:
Interacts with ncoa2.

Subcellular Location:
Nucleus.

Tissue Specificity:
After the mid-blastula transition (MBT), expressed throughout the deep cells, which give rise to the embryo proper. In adults, isoform 2 shows highest expression in the eye and liver. Expressed in adult gonads.

Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

SWISS:
P10827

Gene ID:
7067

Database links:

Entrez Gene: 7067 Human

Entrez Gene: 21833 Mouse

Entrez Gene: 81812 Rat

Omim: 190120 Human

SwissProt: P10827 Human

SwissProt: P63058 Mouse

SwissProt: P63059 Rat

Unigene: 724 Human

Unigene: 265917 Mouse

Unigene: 442648 Mouse

Unigene: 11307 Rat



产品图片
Sample:
Liver (Rat) Lysate at 40 ug
Primary: Anti- Thyroid hormone receptor alpha (bs-6221R) at 1/500 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD
Sample:
Liver (Mouse) Lysate at 40 ug
Primary: Anti-Thyroid hormone receptor alpha (bs-6221R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 55 kD
Observed band size: 55 kD
Blank control(blue): Hela(fixed with 2% paraformaldehyde (10 min) , then permeabilized with 90% ice-cold methanol for 30 min on ice).
Primary Antibody:Rabbit Anti- Thyroid hormone receptor alpha antibody(bs-6221R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions );
Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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