| 产品编号 | bs-6158R |
| 英文名称 | Rabbit Anti-SH2D3A antibody |
| 中文名称 | SH2结构域蛋白3A抗体 |
| 别 名 | Novel SH2 containing protein 1; NSP1; SH2 domain containing 3A; SH2 domain containing protein 3A; SH23A_HUMAN. |
| 研究领域 | 肿瘤 细胞生物 信号转导 转录调节因子 G蛋白偶联受体 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | (predicted: Human,Pig,Sheep,Cow) |
| 产品应用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 63kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NSP1/SH2D3A: 151-250/576 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
SH2D3A is a 576 amino acid protein that is thought to play a role in JNK activation. SH2D3A interacts with p130 Cas and is found at low levels in fetal kidney, fetal lung, placenta, adult pancreas, kidney and lung. Subject to post-translational phosphorylation on multiple tyrosine residues, SH2D3A contains one Src homology 2 (SH2) domain. SH2 domains bind to tyrosine-phosphorylated regions of target proteins, frequently linking activated growth factors to putative signal transduction proteins. The gene encoding SH2D3A maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG families and Fc receptors (FcRs). Function: May play a role in JNK activation. Subunit: Interacts with BCAR1. Tissue Specificity: Weakly expressed in placenta, fetal kidney, fetal lung, adult pancreas, adult kidney and adult lung. Post-translational modifications: Phosphorylated on tyrosine. Similarity: Contains 1 SH2 domain. SWISS: Q9BRG2 Gene ID: 10045 Database links: Entrez Gene: 10045 Human GenBank: BC006281 Human Omim: 604721 Human SwissProt: Q9BRG2 Human Unigene: 439645 Human |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
