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Rabbit Anti-RASA3  antibody (bs-5954R)  
~~~促销,代码KT202502A~~~
~~~促销,代码KT202502B~~~
订购热线:400-901-9800
订购邮箱:sales@bioss.com.cn
订购QQ:  400-901-9800
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-5954R
英文名称 Rabbit Anti-RASA3  antibody
中文名称 Ras-GTP酶激活蛋白3抗体
别    名 GAP III; GAP1(IP4BP); GAP1IP4BP; GAPIII; GTPase activating protein III; Inositol 1 3 4 5 tetrakisphosphate binding protein; Inositol 1345 tetrakisphosphate binding protein; Ins P4 binding protein; Ins(1 3 4 5)P4 binding protein; Ins(1345)P4 binding protein; Ras GTPase activating protein 3; RAS p21 protein activator 3; RASA 3.RASA3_HUMAN  
Specific References  (1)     |     bs-5954R has been referenced in 1 publications.
[IF=4.225] Ke Chen. et al. Tibetan Medicine Duoxuekang Capsule Ameliorates High-Altitude Polycythemia Accompanied by Brain Injury. Front Pharmacol. 2021; 12: 680636  WB,IF ;  Rat.  
研究领域 免疫学  信号转导  G蛋白偶联受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Mouse (predicted: Rat,Pig,Cow,Chicken,Dog,Horse)
产品应用 WB=1:500-2000,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 91kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RASA3: 501-600/834 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 RASA3 is a inhibitory regulator of the Ras-cyclic AMP pathway and is a member of the GAP1 family of GTPase-activating proteins. It stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. RASA3 is an inositol 1,3,4,5-tetrakisphosphate-binding protein (IP4).

Function:
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.

Subcellular Location:
Cell membrane.

Similarity:
Contains 1 Btk-type zinc finger.
Contains 2 C2 domains.
Contains 1 PH domain.
Contains 1 Ras-GAP domain.

SWISS:
Q14644

Gene ID:
22821

Database links:

Entrez Gene: 22821 Human

Entrez Gene: 19414 Mouse

Entrez Gene: 29372 Rat

Omim: 605182 Human

SwissProt: Q14644 Human

SwissProt: Q60790 Mouse

SwissProt: Q9QYJ2 Rat

Unigene: 593075 Human

Unigene: 18517 Mouse

Unigene: 224604 Rat



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