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TGFB4/LEFTY2 Rabbit pAb (bs-5778R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-5778R
英文名称 TGFB4/LEFTY2 Rabbit pAb
中文名称 转化生长因子β4抗体
别    名 EBAF; Endometrial bleeding associated factor(left right determination factor A transforming growth factor beta superfamily); Endometrial bleeding associated factor; Endometrial bleeding-associated factor; Left right determination factor 2; Left right determination factor A; Left-right determination factor 2; Left-right determination factor A; LEFTA; LEFTY 2; LEFTY2; LEFTYA; LFTY2_HUMAN; MGC46222; Protein lefty 2; Protein lefty A; Protein lefty-2; Protein lefty-A; Protein lefty2; PSEC0024; TGF beta 4; TGF-beta-4; TGFB4; Transforming growth factor beta 4; Transforming growth factor beta-4.  
研究领域 肿瘤  免疫学  信号转导  干细胞  生长因子和激素  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human (predicted: Mouse,Rat)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 32 kDa
检测分子量
细胞定位 分泌型蛋白 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human TGFB4: 281-366/366 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 LEFTY2 is a member of the TGF-beta family of proteins. LEFTY2 is secreted and plays a role in left-right asymmetry determination of organ systems during development and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

Function:
Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

Subcellular Location:
Secreted.

Tissue Specificity:
Mesenchymal cells of the endometrial stroma.

Post-translational modifications:
The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

DISEASE:
Defects in LEFTY2 are the cause of left-right axis malformations (LRAM) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.

Similarity:
Belongs to the TGF-beta family.

SWISS:
O00292

Gene ID:
7044

Database links:

Entrez Gene: 7044 Human

Entrez Gene: 320202 Mouse

Entrez Gene: 289316 Rat

Omim: 601877 Human

SwissProt: O00292 Human

SwissProt: P57785 Mouse

Unigene: 520187 Human

Unigene: 87078 Mouse

Unigene: 215726 Rat



产品图片
Sample: A431(Human) Cell Lysate at 30 ug Primary: Anti-LEFTY2  (bs-5778R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 32 kD Observed band size: 32 kD
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