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Rabbit Anti-LARG  antibody (bs-4213R)  
~~~促销,代码KT202502A~~~
~~~促销,代码KT202502B~~~
订购热线:400-901-9800
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价
产品编号 bs-4213R
英文名称 Rabbit Anti-LARG  antibody
中文名称 Rho的鸟嘌呤核苷酸交换因子12抗体
别    名 ARHGEF12; KIAA0382; leukemia-associated rho guanine nucleotide exchange factor; Leukemia-associated RhoGEF; PRO2792; Rho guanine exchange factor (GEF) 12; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12; Similar to Mouse Lsc oncogene; ARHGC_HUMAN.  
Specific References  (1)     |     bs-4213R has been referenced in 1 publications.
[IF=6.314] Otsu et al. The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation. (2016) J.Bone.Miner.Res. 31:1943-1954  IF ;  Mice.  
研究领域 细胞生物  免疫学  信号转导  转录调节因子  G蛋白偶联受体  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog)
产品应用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 173kDa
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LARG: 515-615/1544 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form myeloid/lymphoid fusion partner in acute myeloid leukemia (from EntrezGene). LARG has also been implicated in linking heterotrimeric G proteins to microtubule organisation in regulation of cell polarity.

Function:
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.

Subunit:
Interacts with GNA12 and GNA13, probably through the RGS-like domain, with RHOA, PLXNB1 and PLXNB2, and through its PDZ domain with IGF1R beta subunit.

Subcellular Location:
Cytoplasm. Membrane.

Tissue Specificity:
Expressed in brain, predominantly in neuronal cell bodies.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

DISEASE:
Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with MLL.

Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 RGSL (RGS-like) domain.

SWISS:
Q9NZN5

Gene ID:
23365

Database links:

Entrez Gene: 23365 Human

Entrez Gene: 69632 Mouse

Entrez Gene: 367072 Rat

Omim: 604763 Human

SwissProt: Q9NZN5 Human

SwissProt: Q8R4H2 Mouse

Unigene: 24598 Human

Unigene: 275266 Mouse

Unigene: 129752 Rat



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