| 产品编号 |
bs-0461P |
| 英文名称 |
Cyp2J3 Antibody Blocking Peptide
|
| 中文名称 |
细胞色素P450 2J3封闭多肽 |
| 别 名 |
CYP450 2J3; CYPIIJ3; Cyp2j9; CP2J3_RAT; cytochrome P450, family 2, subfamily j, polypeptide 9; cytochrome P450 monooxygenase; cytochrome P450, 2j9. |
| 克 隆 号 |
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| 理论分子量 |
kDa |
| 检测分子量 |
|
| 性 状 |
Lyophilized |
| 物 种 |
rat |
| 纯化方法 |
1 |
| 活性 |
Not tested |
| 保存条件 |
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 产品介绍 |
bs-0461P is one synthetic peptide derived from rat Cytochrome P450 2J3.
Cytochrome P450s are haem-thiolate proteins involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures.
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