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产品中心-北京博奥森生物技术有限公司
CALCA Antibody Blocking Peptide (bs-0791P)
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说明书: 500ug  
500ug/880.00元
大包装/询价
产品编号 bs-0791P
英文名称 CALCA Antibody Blocking Peptide
中文名称 降钙素基因相关肽1/2封闭多肽
别    名 CGRP-I + CGRP-II; CGRP-1/2; Procalcitonin; Beta type CGRP; CALC2; CALCB; Calcitonin 1; Calcitonin 2; Calcitonin gene related peptide; Calcitonin gene related peptide II; Calcitonin related polypeptide beta; CGRP; CGRP II; CGRP2; CT; Calcitonin/calcitonin related polypeptide alpha; Katacalcin; MGC126648; CALCA_HUMAN; CALCB_HUMAN; Calcitonin gene-related peptide 2; Beta-type CGRP; Beta-CGRP; Calcitonin gene-related peptide II; CGRP-II; CGRP-I.  
Specific References  (1)     |     bs-0791P has been referenced in 1 publications.
[IF=3.877] Zhang et al. Effects of Neuropeptide Substance P on Proliferation and β-Cell Differentiation of Adult Pancreatic Ductal Cells. (2018) Front.Neurosci. 12:806  
性    状 Lyophilized powder
物    种 mouse
纯化方法 HPLC
活性 Not tested
保存条件 Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
产品介绍 CGRP is present in C-cells of the thyroid and in central and peripheral nerves. CGRP has several important physiologic roles: it is a potent vasodilator, and can affect the force and rate of heart beat; it can modulate acetylcholine receptor function at the neuromuscular junction; it has been demonstrated to block tolerance to morphine; and it can modulate antigen presentation in Langerhans cells in the skin. Despite these important physiologic functions, therapeutic strategies using CGRP have been impeded due to the lack of a cloned CGRP receptor with which ligands could be developed.

SWISS:
P06881/P10092

Gene ID:
796/797

CGRP活性多肽,有37个氨基酸组成,具有多种生理功能,其药理作用已受到广泛重视. CGRP (又称CGRP-1/2或CGRPa/β)广泛分布于神经系统的一种神经肽,在外周及脊髓参与伤害性信息的传递及痛敏化的形成,并与P物质、兴奋性氨基酸、辣椒素1型受体、趋化因子、激活素、大麻素受体、阿片受体、神经生长因子、血管活性肠肽、5-羟色胺、糖皮质激素等生物活性物质或受体在痛觉调制过程中存在相互影响。
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