| 产品编号 | Y-0198P |
| 英文名称 | Nogo-66 1-40 (NEP 1-40) Peptide |
| 中文名称 | Nogo-66 (1-40)多肽 |
| 别 名 | Nogo-66(1-40) antagonist peptide; NEP 1-40 peptide; Reticulon-4; Neurite outgrowth inhibitor; Nogo protein; Foocen; Neuroendocrine-specific protein; NSP; Neuroendocrine-specific protein C homolog; RTN-x; Reticulon-5. |
| 克 隆 号 | |
| 理论分子量 | 4.622 kDa |
| 检测分子量 | |
| 性 状 | Lyophilized |
| 物 种 | human |
| 序 列 | Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide, MW: 4622.35 |
| 纯化方法 | HPLC |
| 活性 | Yes |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 产品介绍 |
Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent. Sequence: Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide MW:4622.35 活性多肽：Nogo-66 NEP1-40，能促进神经细胞轴突再生；Nogo-66的末端片断能促进脊髓损伤动物模型神经轴突的再生，并改善功能恢复。 Nogo-A的再生活性片段Nogo-66具有明显的诱导神经干细胞向胶质细胞分化的作用，Nogo-66的胶质分化诱导作用是通过NgR介导的。 氨基酸序列：Acetyl-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-Amide MW:4622.35） |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
