| 产品编号 | bs-0426P |
| 英文名称 | MOG 35-55 (Guinea pig) active peptide |
| 中文名称 | 髓鞘少树突胶质细胞糖蛋白封闭多肽 |
| 别 名 | MOG(35-55); myelin oligo-dendrocyte glycoprotein-MOG; MGC26137; MOG alpha 6; MOG; MOGIG2; Myelin oligodendrocyte glycoprotein; MOG_HUMAN. |
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Specific References (2) | bs-0426P has been referenced in 2 publications.
[IF=3.73] Lin, Jin-Fei, et al. "The Cell Neural Adhesion Molecule Contactin-2 (TAG-1) Is Beneficial for Functional Recovery after Spinal Cord Injury in Adult Zebrafish." PloS one 7.12 (2012): e52376. Other ;
[IF=3.61] Dan Gao. et al. Icariin Ameliorates Behavioral Deficits and Neuropathology in a Mouse Model of Multiple Sclerosis. BRAIN RES. 2023 Jan;:148267 Mouse.
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| 性 状 | Lyophilized powder |
| 物 种 | Guinea pig |
| 序 列 | MEVGWYRSPFSRVVHLYRNGK (Guinea pig) |
| 纯化方法 | HPLC |
| 活性 | Yes |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 产品介绍 |
Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOG's possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ. SWISS: Q61885 Gene ID: 4340 以MOG35-55，多肽为抗原成功诱发EAE模型，该模型发病牢高，病理接近多发性硬化（MS），是研究MS的极为理想的动物模型。以MOG35-55，多肽为抗原成功诱发EAE模型，该模型发病牢高，病理接近多发性硬化（MS），是研究MS的极为理想的动物模型。 Luxol fast blue染色见EAE组脊髓白质脱髓鞘改变；雌、雄大、小鼠在发病率，发病时间，发病程度及病理改变上均无明显差别。结论 本研究以MOG35-55，多肽为抗原成功诱发EAE模型，该模型发病牢靠，病理接近多发性硬化（MS），是研究MS的极为理想的动物模型。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
