| 产品编号 | bs-0107P |
| 英文名称 | Aβ1-42 Peptide |
| 中文名称 | β淀粉样肽（1-42）多肽 |
| 别 名 | beta-Amyloid(1-42); Beta-Amyloid 1-42; A4; AAA; ABETA; ABPP; AD1; Alzheimers Disease Amyloid Protein; Amyloid B; Amyloid Beta A4 Protein Precursor; Amyloid Beta; Amyloid of Aging and Alzheimer Disease; APP; APPI; B Amyloid; Beta APP; Cerebral Vascular Amyloid Peptide; CTFgamma; CVAP; PN II; PN2; PreA4; Protease nexin II; A beta; Amyloid 1-42. |
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Specific References (4) | bs-0107P has been referenced in 4 publications.
[IF=3.994] Chang KW et al. Activation of α7 nicotinic acetylcholine receptor alleviates Aβ1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.Neurochem Int. 2018 Nov;120:238-250. Other ;
[IF=3.361] Wang M et al. 5-HT1AR alleviates Aβ-induced cognitive decline and neuroinflammation through crosstalk with NF-κB pathway in mice. Int Immunopharmacol. 2020 Mar 3;82:106354. other ; mouse.
[IF=2.274] Chang K et al. PNU282987 alleviates Aβ-induced anxiety and depressive-like behaviors through upregulation of α7nAChR by ERK-serotonin receptors pathway. Neurosci Lett
. 2020 Jul 13;731:135118. Other ;
[IF=2.23] Wang, Changfu, et al. "Isolation and screened neuroprotective active constituents from the Roots and Rhizomes of Valeriana amurensis." Fitoterapia (2014). other ; Rat.
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| 理论分子量 | 4.514kDa |
| 性 状 | Lyophilized powder |
| 物 种 | human |
| 序 列 | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA |
| 纯化方法 | HPLC |
| 活性 | Yes |
| 保存条件 | Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 产品介绍 |
Amyloid beta (Aβ or Abeta) denotes peptides of 36–43 amino acids that are crucially involved in Alzheimer's disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield Aβ. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. It is now believed that certain misfolded oligomers (known as "seeds") can induce other Aβ molecules to also take the misfolded oligomeric form, leading to a chain reaction akin to a prion infection. The oligomers are toxic to nerve cells. The other protein implicated in Alzheimer's disease, tau protein, also forms such prion-like misfolded oligomers, and there is some evidence that misfolded Aβ can induce tau to misfold. SWISS: P05067 Gene ID: 351 β-淀粉样蛋白来自β-淀粉样蛋白原，在脑组织的细胞外呈丝状蛋白样沉积 ，是淀粉样结节性神经炎病变的主要蛋白成分，在神经纤维中也有沉积。 在老年性痴呆Alzheimer病中，大脑皮质中特征性地出现β-淀粉样蛋白沉积形成的老年斑。 温馨提示：β淀粉样肽溶解较困难，建议先用少量DMSO溶解，再缓慢加入1×PBS，边加边混匀。注意不要使用混匀器进行操作。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
