| 产品编号 | bs-5098R |
| 英文名称 | IGFBP7 Rabbit pAb |
| 中文名称 | 胰岛素样生长因子结合蛋白7抗体 |
| 别 名 | AGM; Angiomodulin; FSTL2; IBP-7; IBP7; IBP7_HUMAN; IGF binding protein 7; IGF-binding protein 7; IGFBP rP1; IGFBP-7; IGFBP-rP1; IGFBP7; IGFBPRP1; Insulin like growth factor binding protein 7; Insulin-like growth factor-binding protein 7; MAC25; MAC25 protein; PGI2 stimulating factor; PGI2-stimulating factor; Prostacyclin stimulating factor; Prostacyclin-stimulating factor; PSF; RAMSVPS; TAF; Tumor-derived adhesion factor. |
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Specific References (1) | bs-5098R has been referenced in 1 publications.
[IF=4.268] Qin Yang. et al. Gypenoside XLIX protects against acute kidney injury by suppressing IGFBP7/IGF1R-mediated programmed cell death and inflammation. Phytomedicine. 2021 Mar;:153541 WB ; Human.
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| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | Human,Rat (predicted: Mouse,Sheep,Cow,Dog) |
| 产品应用 | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 26 kDa |
| 检测分子量 | |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IGFBP7: 131-230/282 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
IGF-BPs form high affinity complexes with both IGF-I and IGF-II and act to control of the distribution, function and activity of IGFs in various cell tissues and body fluids. There are seven named IGF-BPs. IGFBP7 plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGFBP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. IGFBP7 is expressed in a wide range of normal human tissues and it usually shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. Function: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Subunit: May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear. Subcellular Location: Secreted. Post-translational modifications: N-glycosylated. DISEASE: Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) [MIM:614224]. RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 IGFBP N-terminal domain. SWISS: Q16270 Gene ID: 3490 Database links: Entrez Gene: 3490 Human Entrez Gene: 29817 Mouse Omim: 602867 Human SwissProt: Q16270 Human SwissProt: Q61581 Mouse Unigene: 479808 Human Unigene: 233470 Mouse Unigene: 203012 Rat |
| 产品图片 |
Independently Validated Antibody, image provided by Science Direct, badge number 02663:Formalin-fixed and paraffin embedded human liver labeled with Anti-IGFBP7 Polyclonal Antibody, Unconjugated (bs-5098R) at 1:250 overnight at 25C followed by conjugation to the secondary antibody and DAB staining. Positive Control has great staining, however it may be nonspecific.
Independently Validated Antibody, image provided by Science Direct, badge number 02663:Formalin-fixed and paraffin embedded human kidney labeled with Anti-IGFBP7 Polyclonal Antibody, Unconjugated (bs-5098R) at 1:250 overnight at 25C followed by conjugation to the secondary antibody and DAB staining. Postive Control has great staining, however it may be nonspecific.
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| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
