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Rabbit Anti-ganglioside GM1  antibody (bs-2367R)
~~~促销,代码KX240301~~~
~~~促销,代码KX240302~~~
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说明书: 50ul  100ul  200ul
50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-2367R
英文名称 ganglioside GM1
中文名称 神经节苷酯抗体
别    名 GM1 ganglioside; Monosialoanglioside; ganglioside GM1.  神经节苷脂;
Specific References  (1)     |     bs-2367R has been referenced in 1 publications.
[IF=11.467] Melani Solomon. et al. Altered blood-brain barrier transport of nanotherapeutics in lysosomal storage diseases. J CONTROL RELEASE. 2022 Sep;349:1031  FC ;  Human.  
产品类型 小分子抗体 
研究领域 细胞生物  免疫学  神经生物学  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Rat (predicted: Human,Mouse,Dog,Pig,Cow,Horse,Rabbit,GuineaPig)
产品应用 IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=0.2μg/Test, ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 1.57kDa
细胞定位 细胞浆 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated ganglioside GM1 purified from bovine 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 A member of the family of glycosphingolipids, monosialoanglioside acts as a receptor and antigen for cholera. GM1 ganglioside, one of the glycosphingolipids widely distributed in all tissues, occurs in highest concentrations in the central nervous system (CNS). It is primarily located in the outer surface of the mammalian cell's plasma membrane and in synaptic membranes of the CNS. GM1 ganglioside modulates a number of cell surface and receptor activities as well as neuronal differentiation and development, protein phosphorilation and synaptic function.

Subcellular Location:
Plasma membrane

SWISS:
N/A

CAS:
37758-47-7

含有唾液酸的鞘脂类。克伦克(E.Klenk,1935)首先发现在患Tay-sachs病(泰萨氏幼年型黑白痴病)的小儿脑中有蓄积(Tag-Sachs gangli-oside),在脑灰白质中含量很多,所以对这类糖脂命名为神经节苷脂。已知糖部分是由己糖、氨基糖、唾液酸组成的脑神经节苷脂有8种以上。由山川民夫(1951)在马血球基质中找到的非神经系统的神经节苷脂——主要是血苷脂[hematoside,结构为神经酰胺(1←1β)GLc(4←1β)Gal(3←2α)唾液酸]。神经节苷脂较多地存在于细胞膜,以其与膜功能的关系被引起重视。破伤风菌和霍乱菌的外毒素可与特定的神经节苷脂分子特异性结合。在水和有机溶剂中可溶。在水中是以数百万个分子聚合的微团状态存在。
神经节苷脂对神经再生有重大促进作用。加拿大金爵集团脑科学研究室首席科学家Gatte Walker博士进一步研究发现,神经生长因子(NGF)和神经节苷脂(GM)是脑神经再生发育必需物质,GM介导NGF数十倍增强其活性,形成新的丰富的神经网络,修复并促使脑神经再次发育。
GM能够介导神经生长因子NGF促进脑神经细胞再生,表现出良好的生物效应。——《西安交通医科大学学报》。
产品图片
Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-GM1(GS) Polyclonal Antibody, Unconjugated(bs-2367R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
Blank control:RSC96 (blue).
Primary Antibody: Rabbit Anti-ganglioside GM1/AF647 Conjugated antibody (bs-2367R-AF647), Dilution: 0.2μg in 100 μL 1X PBS containing 0.5% BSA;
Isotype Control Antibody: Rabbit IgG/AF647(orange) ,used under the same conditions.
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