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Thromboxane synthase Rabbit pAb (bs-4019R)  
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50ul/1180.00元
100ul/1980.00元
200ul/2800.00元
大包装/询价

产品编号 bs-4019R
英文名称 Thromboxane synthase Rabbit pAb
中文名称 血栓素合成酶抗体
别    名 CYP5; CYP5A1; Cytochrome P450 5A1; TBXAS1; THAS; Thromboxane A synthase 1 platelet cytochrome P450 subfamily V; TS; TXA synthase; TXAS; TXS.  
研究领域 肿瘤  细胞生物  免疫学  转录调节因子  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human,Mouse (predicted: Rat,Pig,Cow,Dog,Horse)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 59 kDa
检测分子量
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Thromboxane synthase: 451-533/533 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 Thromboxane Synthase is a useful marker for the detection of native thromboxane synthase in smears, isolated cells, human tissue sections, and for affinity purification of the enzyme. In combination with the markers 27E10, RM 3/1 and 25F9, anti Thromboxane Synthase enables a more precise characterization of inflammatory processes in injured tissues, or in vitro cell-cell interaction studies. Distribution of thromboxane synthase in human tissues: Thromboxane synthase is predominantly produced by macrophages or antigen presenting cells of the myelo-monocytic lineage as shown below. Endothelial cells of placenta and epithelial cells in tonsils and bronchi also express this enzyme.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Platelets, lung, kidney, spleen, macrophages and lung fibroblasts.

DISEASE:
Defects in TBXAS1 are the cause of Ghosal hematodiaphyseal dysplasia (GHDD) [MIM:231095]. GHDD is a rare autosomal recessive disorder characterized by increased bone density with predominant diaphyseal involvement and aregenerative corticosteroid-sensitive anemia. Aregenerative anemia is characterized by bone marrow failure, so that functional marrow cells are regenerated slowly or not at all.
Defects in TBXAS1 are the cause of thromboxane synthetase deficiency (TBXAS1 deficiency) [MIM:274180]. It is characterized by hemorrhagic diathesis.

Similarity:
Belongs to the cytochrome P450 family.

SWISS:
P24557

Gene ID:
6916

Database links:

Entrez Gene: 6916 Human

Entrez Gene: 21391 Mouse

Entrez Gene: 397112 Pig

Entrez Gene: 24886 Rat

Omim: 274180 Human

SwissProt: P24557 Human

SwissProt: P36423 Mouse

SwissProt: P47787 Pig

SwissProt: P49430 Rat

Unigene: 520757 Human

Unigene: 4054 Mouse

Unigene: 16283 Rat



产品图片
Sample: U937(Human) Cell Lysate at 30 ug Spleen (Mouse) Lysate at 40 ug Primary: Anti-Thromboxane synthase (bs-4019R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 59 kD
Sample: A549(Human) Cell Lysate at 30 ug Primary: Anti-Thromboxane synthase (bs-4019R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 59 kD
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