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Rabbit Anti-SUR1 antibody (bs-3641R)
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说明书: 50ul  100ul  200ul
50ul/780.00元
100ul/1380.00元
200ul/2200.00元
大包装/询价

产品编号 bs-3641R
英文名称 SUR1
中文名称 磺酰脲类药物受体1抗体
别    名 ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1); HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.  
规格价格 50ul/780元 购买    100ul/1380元 购买    200ul/2200元 购买    大包装/询价
说 明 书 50ul  100ul  200ul
研究领域 免疫学  细胞膜受体  药物及化合物  糖尿病  内分泌病  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Horse, Guinea Pig, 
产品应用 WB=1:500-2000 ELISA=1:500-1000 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 175kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human SUR1:301-400/1581 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
产品介绍 background:
SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.

Subunit:
Interacts with KCNJ11.

Subcellular Location:
Membrane; Multi-pass membrane protein.

Similarity:
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
Contains 2 ABC transmembrane type-1 domains.
Contains 2 ABC transporter domains.

SWISS:
Q09428

Gene ID:
6833

Database links:

Entrez Gene: 6833 Human

Entrez Gene: 20927 Mouse

Entrez Gene: 25559 Rat

Omim: 600509 Human

SwissProt: Q09428 Human

SwissProt: Q09429 Rat

Unigene: 54470 Human

Unigene: 11187 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰岛β细胞膜含有磺酰脲受体及与之相偶联的ATP敏感的钾通道Ik(ATP),以及电压依赖性的钙通道。当磺酰脲类药物与其受体相结合后,可阻滞Ik(ATP)而阻钾外流,致使细胞膜去极化,增强电压依赖性钙通道开放,胞外钙内流。胞内游离钙浓度增加后,触发胞吐作用及胰岛素的释放。
产品图片
Sample:
Hippocampus (Mouse) Lysate at 40 ug
Primary: Anti-SUR1 (bs-3641R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 175 kD
Observed band size: 175 kD
Sample:
Cerebral cortex (Mouse) Lysate at 40 ug
Primary: Anti-SUR1 (bs-3641R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 175 kD
Observed band size: 175 kD
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