| 产品编号 | bs-2765R |
| 英文名称 | BMX Rabbit pAb |
| 中文名称 | 非受体性蛋白酪氨酸激酶ETK抗体 |
| 别 名 | ETK; PSCTK2; PSCTK3; Etk/Bmx; Tyro8; RGD1565643; BMX_HUMAN; BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase (ETK); NTK38; 2.7.10.2; BMX_MOUSE; Bone marrow tyrosine kinase gene in chromosome X prote |
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Specific References (1) | bs-2765R has been referenced in 1 publications.
[IF=6.208] Xingdong Wang. et al. Single-Cell RNA Sequencing Reveals Atlas of Yak Testis Cells. INT J MOL SCI. 2023 Jan;24(9):7982 IHC ; Bovine.
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| 研究领域 | 肿瘤 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 克 隆 号 | |
| 交叉反应 | (predicted: Human,Mouse,Rat,Rabbit,Pig,Cow,Dog,Horse) |
| 产品应用 | WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理论分子量 | 78 kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | Synthetic peptide from the human BMX conjugated to KLH: 571-675/675 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 缓 冲 液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 保存条件 | Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 产品介绍 |
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]. Function: Non-receptor tyrosine kinase that plays central butdiverse modulatory roles in various signaling processes involved inthe regulation of actin reorganization, cell migration, cellproliferation and survival, cell adhesion, and apoptosis.Participates in signal transduction stimulated by growth factorreceptors, cytokine receptors, G-protein coupled receptors, antigenreceptors and integrins. Induces tyrosine phosphorylation of BCAR1in response to integrin regulation. Activation of BMX by integrinsis mediated by PTK2/FAK1, a key mediator of integrin signalingevents leading to the regulation of actin cytoskeleton and cellmotility. Plays a critical role in TNF-induced angiogenesis, andimplicated in the signaling of TEK and FLT1 receptors, 2 importantreceptor families essential for angiogenesis. Required for thephosphorylation and activation of STAT3, a transcription factorinvolved in cell differentiation. Also involved in interleukin-6(IL6) induced differentiation. Plays also a role in programmingadaptive cytoprotection against extracellular stress in differentcell systems, salivary epithelial cells, brain endothelial cells,and dermal fibroblasts. May be involved in regulation ofendocytosis through its interaction with an endosomal proteinRUFY1. May also play a role in the growth and differentiation ofhematopoietic cells; as well as in signal transduction inendocardial and arterial endothelial cells. Subunit: Interacts with BCAR1, CAV1, MYD88, PTK2/FAK1, RUFY1,RUFY2, STAT3, TIRAP and TNFRSF1B. Subcellular Location: Cytoplasm. Note=Localizes to the edges ofspreading cells when complexed with BCAR1. Tissue Specificity: Highly expressed in cells with great migratorypotential, including endothelial cells and metastatic carcinomacell lines. Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. Contains 1 Btk-type zinc finger. Contains 1 PH domain. Contains 1 protein kinase domain. Contains 1 SH2 domain. SWISS: P51813 Gene ID: 660 Database links: Entrez Gene: 660 Human Entrez Gene: 12169 Mouse Omim: 300101 Human SwissProt: P51813 Human SwissProt: P97504 Mouse Unigene: 495731 Human Unigene: 504 Mouse Etk属非受体性蛋白酪氨酸激酶BTK家族成员之一，主要表达于上皮和内皮细胞，在调控细胞的增殖及凋亡等信号转导过程中起着重要的作用。Etk与肿瘤发生发展、分化增值密切相关。 |
| 1、抗体溶解方法 | |
| 2、抗体修复方式 | |
| 3、常用试剂的配制 | |
| 4、免疫组化操作步骤 | |
| 5、免疫组化问题解答 | |
| 6、Western Blotting 操作步骤 | |
| 7、Western Blotting 问题解答 | |
| 8、关于肽链的设计 | |
| 9、多肽的溶解与保存 | |
| 10、酶标抗体效价测定程序 | |
