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phospho-ACLY (Ser455) Rabbit pAb (bs-3037R)  
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产品编号 bs-3037R
英文名称 phospho-ACLY (Ser455) Rabbit pAb
中文名称 磷酸化三磷酸腺柠檬酸裂解酶抗体
别    名 ATP citrate lyase(phospho S455); ACL; ATP citrate(pro-S) lyase; ATP citrate synthase; Citrate cleavage enzyme; EC 2.3.3.8; A730098H14RIK; ACLY; ATP CITRATE LYASE; ATPCL; AW538652; Cce; CITRATE LYASE; CLATP; MGC124629; ACL; ACLY_HUMAN; ATP citrate lyase; ATP-citrate(pro-S-)-lyase; ATP-citrate synthase; ATPcitrate synthase;  
产品类型 磷酸化抗体 
研究领域 肿瘤  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
克 隆 号
交叉反应 Human (predicted: Mouse,Rat,Pig,Sheep,Cow,Chicken,Dog,Horse)
产品应用 WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 122 kDa
检测分子量
细胞定位 细胞浆 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human ACLY around the phosphorylation site of Ser455: TA(p-S)FS 
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Function:
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Subunit:
Homotetramer.

Subcellular Location:
Cytoplasm.

Post-translational modifications:
ISGylated.
Acetylated at Lys-540, Lys-546 and Lys-554 by KAT2B/PCAF. Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites. Acetylation promotes de novo lipid synthesis. Deacetylated by SIRT2.
Ubiquitinated at Lys-540, Lys-546 and Lys-554 by UBR4, leading to its degradation. Ubiquitination is probably inhibited by acetylation at same site.

Similarity:
In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.
In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.

SWISS:
P53396

Gene ID:
47

Database links:

Entrez Gene: 47 Human

Entrez Gene: 104112 Mouse

Entrez Gene: 24159 Rat

Omim: 108728 Human

SwissProt: P53396 Human

SwissProt: Q91V92 Mouse

SwissProt: P16638 Rat

Unigene: 387567 Human

Unigene: 282039 Mouse

Unigene: 29771 Rat



产品图片
Sample: A549(Human) Cell Lysate at 30 ug U87MG(Human) Cell Lysate at 30 ug MOLT-4(Human) Cell Lysate at 30 ug Primary: Anti- phospho-ATP citrate lyase (Ser455) (bs-3037R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 122 kD Observed band size: 122 kD
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