产品中心-北京博奥森生物技术有限公司

产品编号	bs-2713R
英文名称	HAVCR1 Rabbit pAb
中文名称	肾损伤分子1/甲型肝炎病毒细胞受体1抗体
别名	HAVCR; HAVCR 1; HA; Vcr-1; hepatitis A virus cellular receptor 1; HKIM-1; Kidney Injury Molecule1; KIM1; KIM 1; KIM-1; TIM-1; TIMD 1; TIMD1; KM-1; TIMD1_HUMAN; T cell immunoglobin domain and mucin domain protein 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell membrane protein 1. 肾脏损伤分子1
	Specific References (14) \| bs-2713R has been referenced in 14 publications. [IF=11.556] Wen-juan Jiang. et al. Tubular epithelial cell-to-macrophage communication forms a negative feedback loop via extracellular vesicle transfer to promote renal inflammation and apoptosis in diabetic nephropathy. Theranostics. 2022; 12(1): 324–339 WB ; Mouse,Human. PubMed:34987648 [IF=9.473] Xiao-yan He. et al. Cpd-42 Alleviates Acute Kidney Injury via Targeting RIPK3-mediated Necroptosis. BRIT J PHARMACOL. 2023 May;: IHC,WB ; Mouse. PubMed:37248964 [IF=7.31] Huang Yue-bo. et al. Melatonin Alleviates Acute Kidney Injury by Inhibiting NRF2/Slc7a11 Axis-Mediated Ferroptosis. OXID MED CELL LONGEV. 2022;2022:4776243 IHC, IF ; Mouse. PubMed:35979396 [IF=6.691] Jiang, Wenjuan. et al. Macrophage-derived, LRG1-enriched extracellular vesicles exacerbate aristolochic acid nephropathy in a TGFβR1-dependent manner. 2021 Oct 22 WB,IF ; Mouse. PubMed:34677723 [IF=6.304] Zhu H et al. PSTPIP2 inhibits cisplatin-induced acute kidney injury by suppressing apoptosis of renal tubular epithelial cellsCell Death Dis.2020 Dec 12;11(12):1057. IF、WB ; Mouse. PubMed:33311489 [IF=5.275] Ming-jun Yu. et al. Discovery of a Novel GRPR Antagonist for Protection against Cisplatin-Induced Acute Kidney Injury. BIOORG CHEM. Bioorg Chem. 2022 Apr;:105794 WB ; Mouse,Human. PubMed:35533545 [IF=5.085] WB , IF ; PubMed:32194547 [IF=5.064] Fang Wang. et al. Stratifin promotes renal dysfunction in ischemic and nephrotoxic AKI mouse models via enhancing RIPK3-mediated necroptosis. Acta Pharmacol Sin. 2021 Apr;:1-12 WB,IF,IHC ; Human, Mouse. PubMed:33833407 [IF=3.448] Topdağı Ö et al. Preventive effects of fraxin on ischemia/reperfusion-induced acute kidney injury in rats. Life Sci. 2020 Feb 1;242:117217. IHC ; Rat. PubMed:31884094 [IF=3.292] Ademola Adetokunbo Oyagbemi. et al. Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-кB/Kim-1 signaling in the heart and kidney of rats. Environ Toxicol Phar. 2020 Nov;80:103488 IHC ; Rat. PubMed:32898663 [IF=3.222] Pengmin Ji. et al. Ginsenoside Rg1 treatment alleviates renal fibrosis by inhibiting the NOX4–MAPK pathway in T2DM mice. RENAL FAILURE. 2023;45(1):Article: 2197075 WB ; Mouse. PubMed:37017270 [IF=2.491] Oyagbemi AA et al. Ameliorative effect of Rutin on sodium fluoride‐induced hypertension through modulation of Kim‐1/NF‐κB/Nrf2 signaling pathway in rats.(2018)Environ Toxicol. IHC ; Rat. PubMed:30259632 [IF=1.718] Selim Çomaklı. et al. Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB/p53 and Bcl-2 expression. 2022 Jan 17 IHC ; Rat. PubMed:35037524 [IF=0] Gülden Diniz. et al. Tissue Expression of Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 in Breast Cancers.. European Journal of Breast Health. 2022 Oct;18(4):336-342 IHC ; Human. PubMed:36248749
研究领域	细胞生物免疫学细胞膜受体细菌及病毒
抗体来源	Rabbit
克隆类型	Polyclonal
克隆号
交叉反应	Human,Mouse,Rat
产品应用	WB=1:500-2000 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
理论分子量	39 kDa
检测分子量
细胞定位	细胞膜
性状	Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human HAVCR1: 51-150/359 <Extracellular>
亚型	IgG
纯化方法	affinity purified by Protein A
缓冲液	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件	Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
产品介绍	The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] Function: May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair. Subcellular Location: Membrane; Single-pass type I membrane protein (Probable). Tissue Specificity: Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. Similarity: Belongs to the immunoglobulin superfamily. TIM family. Contains 1 Ig-like V-type (immunoglobulin-like) SWISS: Q96D42 Gene ID: 26762 Database links: Entrez Gene: 26762 Human Entrez Gene: 171283 Mouse Entrez Gene: 286934 Rat Omim: 606518 Human SwissProt: Q96D42 Human SwissProt: Q5QNS5 Mouse SwissProt: O54947 Rat Unigene: 129711 Human Unigene: 17771 Mouse Unigene: 11154 Rat
产品图片	Sample: Lane 1: Mouse Testis tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Mouse Thymus tissue lysates Lane 4: Rat Testis tissue lysates Lane 5: Rat Cerebrum tissue lysates Lane 6: Rat Thymus tissue lysates Lane 7: Human A549 cell lysates Lane 8: Human A431 cell lysates Primary: Anti-HAVCR1 (bs-2713R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kDa Observed band size: 50 kDa

	免疫组化常用试剂
	免疫印迹常用试剂
	各种标记二抗

	1、抗体溶解方法
	2、抗体修复方式
	3、常用试剂的配制
	4、免疫组化操作步骤
	5、免疫组化问题解答
	6、Western Blotting 操作步骤
	7、Western Blotting 问题解答
	8、关于肽链的设计
	9、多肽的溶解与保存
	10、酶标抗体效价测定程序

	AbBy Fluor 350 标记
	AbBy Fluor 488 标记
	AbBy Fluor 555 标记
	AbBy Fluor 594 标记
	AbBy Fluor 647 标记
	AP 标记
	APC 标记
	Biotin 标记
	Cy3 标记
	Cy5 标记
	Cy5.5 标记
	Cy7 标记
	FITC 标记
	Gold 标记
	HRP 标记
	PE 标记
	PE-Cy3 标记
	PE-CY5 标记
	PE-CY5.5 标记
	PE-CY7 标记
	RBITC 标记