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Rabbit Anti-RANK antibody (bs-2695R)
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产品编号 bs-2695R
英文名称 Rabbit Anti-RANK antibody
中文名称 核转录因子NF-κB受体抗体(核因子kB受体活化因子)
别    名 TNFRSF11A; CD265; CD265 antigen; Activator of NFKB; EOF; FEO; mRANK; NFKB activator; ODFR; OFE; Osteoclast differentiation factor receptor; PDB 2; Receptor activator of NF KB; receptor activator of nuclear factor kappa B; TNFRSF 11A; TNFSF11; TRANCE R; RANK receptor; TNR11_HUMAN.   
Specific References  (9)     |     bs-2695R has been referenced in 9 publications.
[IF=12.441] Gao FP et al. Au Clusters Treat Rheumatoid Arthritis with Uniquely Reversing Cartilage/Bone Destruction. Adv. Sci. 2019, 1801671.  IHC ;  Rat.  
[IF=5.923] Nanami Nakamura. et al. Possible Action of Olaparib for Preventing Invasion of Oral Squamous Cell Carcinoma In Vitro and In Vivo. Int J Mol Sci. 2022 Jan;23(5):2527  WB ;  Mouse.  
[IF=5.115] Yuan L et al. La2O3 Nanoparticles Induce Reproductive Toxicity Mediated by the Nrf-2/ARE Signaling Pathway in Kunming Mice. Int J Nanomedicine. 2020 May 14;15:3415-3431.  IHC ;  Mouse.  
[IF=4.825] Li L et al. Janus kinase inhibitor ruxolitinib blocks thymic regeneration after acute thymus injury. Biochem Pharmacol. 2019 Nov 11;171:113712.  IHF-F&ICF-F ;  Mouse.  
[IF=3.297] Hongyi Qu. et al. The effects of vasoactive intestinal peptide on RANKL-induced osteoclast formation. Ann Transl Med. 2021 Jan; 9(2): 127  WB ;  Rat.  
[IF=2.65] Cao Lu. et al. Exploring the Action Mechanism of the Active Ingredient of Quercetin in Ligustrum lucidum on the Mouse Mastitis Model Based on Network Pharmacology and Molecular Biology Validation. EVID-BASED COMPL ALT. 2022;2022:4236222  WB ;  Rat.  
[IF=2.304] Teng X et al. Effects of Low Dietary Phosphorus on Tibia Quality and Metabolism in Caged Laying Hens. Prev Vet Med . 2020 Aug;181:105049.  WB ;  Hen.  
[IF=1.785] Qianwen Lv. et al. Effects of lentinan on NF‑κB activity in the liver of burn rats with sepsis. Exp Ther Med. 2020 Sep;20(3):2279-2283  
[IF=0] Francesca Punzoet al. Can Denosumab be used in combination with Doxorubicin in Osteosarcoma?. Oncotarget . 2020 Jul 14;11(28):2763-2773.  WB ;  Human.  
研究领域 肿瘤  细胞生物  转录调节因子  细胞表面分子  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human,Mouse (predicted: Rat)
产品应用 WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,Flow-Cyt=1μg /test,IF=1:100-500,ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量 66kDa
检测分子量 82-90 kDa
细胞定位 细胞膜 
性    状 Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human RANK: 51-150/616 <Extracellular>
亚    型 IgG
纯化方法 affinity purified by Protein A
缓 冲 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项 This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
产品介绍 The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]

Function:
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.

Subcellular Location:
Membrane.

Tissue Specificity:
Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

DISEASE:
Defects in TNFRSF11A are the cause of familial expansile osteolysis (FEO) [MIM:174810]. FEO is a rare autosomal dominant bone disorder characterized by focal areas of increased bone remodeling. The osteolytic lesions develop usually in the long bones during early adulthood. FEO is often associated with early onset deafness and loss of dentition.
Defects in TNFRSF11A are a cause of Paget disease of bone type 2 (PDB2) [MIM:602080]; also known as familial Paget disease of bone. PDB2 is a bone-remodeling disorder with clinical similarities to FEO. Unlike FEO, however, affected individuals have involvement of the axial skeleton with lesions in the spine, pelvis and skull.

Similarity:
Contains 4 TNFR-Cys repeats.

SWISS:
Q9Y6Q6

Gene ID:
8792

Database links:

Entrez Gene: 8792 Human

Omim: 603499 Human

SwissProt: Q9Y6Q6 Human

Unigene: 204044 Human



产品图片
Sample: U251 Cell Lysate at 30 ug Primary: Anti- RANK (bs-2695R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63-70 kD Observed band size: 63 kD
Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti-RANK (bs-2695R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 63-70 kD Observed band size: 70 kD
Blank control(blue):Jurkat cells (fixed with 2% paraformaldehyde (10 min)). Primary Antibody:Rabbit Anti-RANK antibody(bs-2695R), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG(orange) ,used under the same conditions ); Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA.
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